Figure 2: In silico analysis of messenger RNA structure and stability of c. 4845 G>A (p.V1615V) in LRRK2 using Mfold. The mRNA secondary structure is stabilized by hydrogen bonds, represented by three different colours; AU, blue, CG, red and GU, green. The nucleotide position has been indicated by a small asterisk and the regions altered in mutant are indicated by arrows. Inset showing part of image in enlarged form. (A) Wild type and (B) Mutant.