Figure 1: In silico analysis of mRNA structure and stability of c. 4581 T>C (p.Y1527Y) in leucine-rich repeat kinase 2 ( LRRK2) using Mfold. The nucleotide position has been indicated by a small asterisk . The mRNA secondary structure is stabilized by hydrogen bonds, represented by three different colours; AU blue, CG red and GU green. Inset showing part of image in enlarged form. (A) Wild type and (B) Mutant (no changes were found in this mutant).