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  Indian J Med Microbiol
 

Figure 4: (A&B) In vitro osteoarthritis chondrocyte-fibrin constructs derived from cells seeded at low and high densities at days 7, 14 and 21, showing cells of various shapes and sizes. Positive Safranin O (magnification: 200μm) staining confirmed the presence of cartilage-specific proteoglycan (C). The diameter of the high-density seeding construct was significantly bigger compared to that of the low-density construct at days 14 and 21 (*P <0.05), with a difference of 2.1 and 1.6 mm, respectively (D&E). Image showing the cell distribution and aggregates in the fibrin construct seeded with chondrocytes at low and high densities at different time points (day 7, 14 and 21).

Figure 4: (<b>A&B</b>) <i>In vitro</i> osteoarthritis chondrocyte-fibrin constructs derived from cells seeded at low and high densities at days 7, 14 and 21, showing cells of various shapes and sizes. Positive Safranin O (magnification: 200μm) staining confirmed the presence of cartilage-specific proteoglycan (<b>C</b>). The diameter of the high-density seeding construct was significantly bigger compared to that of the low-density construct at days 14 and 21 (<sup>*</sup><i>P</i> <0.05), with a difference of 2.1 and 1.6 mm, respectively (<b>D&E</b>). Image showing the cell distribution and aggregates in the fibrin construct seeded with chondrocytes at low and high densities at different time points (day 7, 14 and 21).