Figure 5: Representative photomicrographs of histopathological examination of (A) brain and (B) lungs section (5 μm) of control and CNS-TB mice stained with haematoxylin and eosin. Mice were sacrificed 30 and 50 days after intravenous infection with Mycobacterium tuberculosis C3 strain. Organs (n=4) were used for histological examination. Gross pathological examination of brain sections of CNS-TB mice showed lymphocytic proliferation (arrows) with development of oedema of brain parenchyma which was more prominent at 50 days post-infection. Analysis of lung section at 30 days revealed high lymphocytic infiltarion, with alveolar space mostly filled with inflammatory cells (arrows) and oedematous fluid. This gross lung pathology was considerably less on examination at 50 days post-infection (×100).