Figure 1. Genomic organization of FTO region in high linkage disequilibrium (LD) to its neighbouring genes. The FTO variants rs1421085, rs9939609, rs8050136 and rs1781744 are reported to act as long range enhancers for IRX3 gene, believed to be master regulator of obesity. The enhancers located in FTO are also believed to influence the expression of other cis-located neighbouring genes such as IRX5, IRX6, RPGRIPL1 and FTS which may also contribute to obesity phenotype. SNP, single nucleotide polymorphism