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  Indian J Med Microbiol
 

Figure 5: Schematic model. A novel hypothesis depicting the possible role of stress induced premature senescence (SIPS) in ovarian tumorigenesis, orchestrated through genomic and epigenomic level alterations. ATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia Rad3 related; p16 INK4, p16 inhibitor of cyclin dependent kinase 4; Rb, retinoblastoma; CDCK2, cyclin dependent kinase 2; E2F, elongation 2 promoter binding factor; SA-â-gal, senescence associated beta galactosidase, SAHF, senescence associated heterochromating foci, SASP, senescence associated secretory phenotype.

Figure 5: Schematic model. A novel hypothesis depicting the possible role of stress induced premature senescence (SIPS) in ovarian tumorigenesis, orchestrated through genomic and epigenomic level alterations. ATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia Rad3 related; p16 INK4, p16 inhibitor of cyclin dependent kinase 4; Rb, retinoblastoma; CDCK2, cyclin dependent kinase 2; E2F, elongation 2 promoter binding factor; SA-â-gal, senescence associated beta galactosidase, SAHF, senescence associated heterochromating foci, SASP, senescence associated secretory phenotype.