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  Indian J Med Microbiol
 

Figure 1: Persistent DNA damage response: Representative immunofluorescence microphotographs (X200) showing accumulation of oxidative DNA marker 8-oxo-2'-deoxy guanosine (8-OH/dG), persistent DNA damage response with activated DNA damage response (DDR) mediators phosphorylated ataxia telengiectasia mutated (ATM) and γH2AX (phosphorylated H2AX) showing significant punctuated nuclear patterns and distinct interspersed foci respectively in B/CMBA.Ov (mouse ovarian epithelial) cells following treatment with 0.005 μM MIC at 48 h in comparison to controls.

Figure 1: Persistent DNA damage response: Representative immunofluorescence microphotographs (X200) showing accumulation of oxidative DNA marker 8-oxo-2'-deoxy guanosine (8-OH/dG), persistent DNA damage response with activated DNA damage response (DDR) mediators phosphorylated ataxia telengiectasia mutated (ATM) and γH2AX (phosphorylated H2AX) showing significant punctuated nuclear patterns and distinct interspersed foci respectively in B/CMBA.Ov (mouse ovarian epithelial) cells following treatment with 0.005 μM MIC at 48 h in comparison to controls.