Figure 6: Schematic model depicting the proposed signaling pathway in LH/hCG-induced LHR mRNA down regulation. Binding of ligand to LH receptor induces activation of ERK1/2 through the cAMP/PKA pathway. This leads to an increase in the expression of LRBP and thereby its LHR mRNA binding activity, which ultimately results in LHR mRNA degradation. (Source: Ref. 27, Reproduced with permission).