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  Indian J Med Microbiol
 

Figure 6: Schematic model depicting the proposed signaling pathway in LH/hCG-induced LHR mRNA down regulation. Binding of ligand to LH receptor induces activation of ERK1/2 through the cAMP/PKA pathway. This leads to an increase in the expression of LRBP and thereby its LHR mRNA binding activity, which ultimately results in LHR mRNA degradation. (Source: Ref. 27, Reproduced with permission).

Figure 6: Schematic model depicting the proposed signaling pathway in LH/hCG-induced LHR mRNA down regulation. Binding of ligand to LH receptor induces activation of ERK1/2 through the cAMP/PKA pathway. This leads to an increase in the expression of LRBP and thereby its LHR mRNA binding activity, which ultimately results in LHR mRNA degradation. (<i>Source</i>: Ref. 27, Reproduced with permission).