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  Indian J Med Microbiol
 

Figure 3. Association of HPV16 physical state with the viral load in different precancer and cancer cases. Distribution of normalized HPV16 E2:E6 ratio and HPV 16 viral load in cervical precancer (LSIL and HSIL) and cancer cases. Each circle indicates individual case. Normalized E2:E6 ratios and viral load were calculated as described in Methods. Normalized E2:E6 = 0 represents completely integrated HPV16; E2:E6 = 1 represents episomal viral genome, E2:E6 between 0 and 1 indicates concomitant HPV16 genome. Vertical red line and horizontal blue line represent median values of E2:E6 ratio and HPV16 viral load in each disease group, respectively.

Figure 3. Association of HPV16 physical state with the viral load in different precancer and cancer cases. Distribution of normalized HPV16 E2:E6 ratio and HPV 16 viral load in cervical precancer (LSIL and HSIL) and cancer cases. Each circle indicates individual case. Normalized E2:E6 ratios and viral load were calculated as described in Methods. Normalized E2:E6 = 0 represents completely integrated HPV16; E2:E6 = 1 represents episomal viral genome, E2:E6 between 0 and 1 indicates concomitant HPV16 genome. Vertical red line and horizontal blue line represent median values of E2:E6 ratio and HPV16 viral load in each disease group, respectively.