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   2010| April  | Volume 131 | Issue 4  
    Online since April 16, 2011

 
 
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REVIEW ARTICLE
Clinical spectrum & pathogenesis of Clostridium difficile associated diseases
C Vaishnavi
April 2010, 131(4):487-499
PMID:20424299
Clostridium difficile is the major aetiological agent of antibiotic associated diarrhoea and colitis. The majority of hospitalized patients infected by C. difficile are asymptomatic carriers who serve as silent reservoirs for continued C. difficile contamination of the hospital environment. C. difficile associated disease (CDAD) is a serious condition with mortality up to 25 per cent in frail elderly people. C. difficile infection may present itself in several forms with both colonic and extracolonic manifestations. Several factors are involved in determining whether or not a patient develops C. difficile infection. These include factors related to the pathogen as well as the host. Transmission of C. difficile can be endogenous or exogenous. Colonization of the pathogen occurs when the gut flora gets disrupted due to various factors. The main virulence factors for CDAD are the two potent toxins: toxin A and toxin B which share 63 per cent of amino acid sequence homology and act on small guanosine triphosphate binding proteins. The emergence of the global hypervirulent C. difficile strain has been a cause of concern. Diagnosis of CDAD infection can be done by detection of C. difficile toxin in the stool specimen. Vancomycin is the drug of choice for severely ill patient, whereas metronidazole can be used for mild to moderately ill patients. Clinical spectrum, the factors precipitating CDAD, pathogenesis, diagnostic assay and treatment of the disease are reviewed.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  225 1,378 -
ORIGINAL ARTICLES
Infectious aetiology of congenital cataract based on TORCHES screening in a tertiary eye hospital in Chennai, Tamil Nadu, India
B Mahalakshmi, K Lily Therese, U Devipriya, V Pushpalatha, S Margarita, HN Madhavan
April 2010, 131(4):559-564
PMID:20424308
Full text not available  [PDF]  [PubMed]
  126 661 -
Novel mutations in Indian patients with autosomal recessive infantile malignant osteopetrosis
Shubha R Phadke, B Fischer, N Gupta, P Ranganath, M Kabra, U Kornak
April 2010, 131(4):508-514
PMID:20424301
Full text not available  [PDF]  [PubMed]
  116 644 -
EDITORIALS
Nutritional composition & health benefits of organic foods - using systematic reviews to question the available evidence
Alan D Dangour, E Allen, K Lock, R Uauy
April 2010, 131(4):478-480
PMID:20424296
Full text not available  [PDF]  [PubMed]
  132 601 -
ORIGINAL ARTICLES
Thimerosal exposure & increasing trends of premature puberty in the vaccine safety datalink
David A Geier, Heather A Young, Mark R Geier
April 2010, 131(4):500-507
PMID:20424300
Full text not available  [PDF]  [PubMed]
  134 564 -
Paraoxonase gene Q192R & L55M polymorphisms in Indians with acute myocardial infarction & association with oxidized low density lipoprotein
R Lakshmy, D Ahmad, Rani Ann Abraham, M Sharma, K Vemparala, S Das, K Srinath Reddy, D Prabhakaran
April 2010, 131(4):522-529
PMID:20424303
Full text not available  [PDF]  [PubMed]
  118 511 -
Iron regulated outer membrane proteins (IROMPs) as potential targets against carbapenem-resistant Acinetobacter spp. isolated from a Medical Centre in Malaysia
Wong Eng Hwa, G Subramaniam, Marzida Bt Mansor, Ong Siok Yan, Deepa Anbazhagan, Sekaran Shamala Devi
April 2010, 131(4):578-583
PMID:20424311
Full text not available  [PDF]  [PubMed]
  93 494 -
Clinical & molecular characterization of human TT virus in different liver diseases
M Asim, R Singla, RK Gupta, P Kar
April 2010, 131(4):545-554
PMID:20424306
Full text not available  [PDF]  [PubMed]
  122 435 -
Prevalence of health related disability among community dwelling urban elderly from middle socioeconomic strata in Bangaluru, India
K Srinivasan, M Vaz, T Thomas
April 2010, 131(4):515-521
PMID:20424302
Full text not available  [PDF]  [PubMed]
  104 426 -
Efficacy of cabergoline on rapid escalation of dose in men with macroprolactinomas
A Bhansali, R Walia, P Dutta, N Khandelwal, R Sialy, S Bhadada
April 2010, 131(4):530-535
PMID:20424304
Full text not available  [PDF]  [PubMed]
  100 387 -
Post-operative endophthalmitis : Antibiogram & genetic relatedness between Pseudomonas aeruginosa isolates from patients & phacoemulsifiers
G Satpathy, D Patnayak, Jeewan Singh Titiyal, N Nayak, R Tandon, N Sharma, Rasik Behari Vajpayee
April 2010, 131(4):571-577
PMID:20424310
Full text not available  [PDF]  [PubMed]
  107 305 -
COMMENTARIES
Exposure to low-dose mercury (from thimerosal) & premature puberty - a new avenue for research with the vaccine safety datalink
José G Dórea
April 2010, 131(4):481-483
PMID:20424297
Full text not available  [PDF]  [PubMed]
  91 303 -
ORIGINAL ARTICLES
Detection, amplification & sequence homology of sodC in clinical isolates of Salmonella sp.
MK Sanjay, SM Shrideshikan, MS Usha, A Philipraj, SM Gaddad, CT Shivannavar
April 2010, 131(4):565-570
PMID:20424309
Full text not available  [PDF]  [PubMed]
  108 282 -
CORRESPONDENCES
Fatal Burkholderia pseudomallei septicaemia in a patient with diabetes
RD Kulkarni, P Jain, GS Ajantha, J Shetty, S Chunchanur, C Shubhada
April 2010, 131(4):584-585
PMID:20424312
Full text not available  [PDF]  [PubMed]
  142 225 -
ORIGINAL ARTICLES
Transplantation of retinoic acid treated murine embryonic stem cells & behavioural deficit in Parkinsonian rats
F Fathi, T Altiraihi, Seyed Javad Mowla, M Movahedin
April 2010, 131(4):536-544
PMID:20424305
Full text not available  [PDF]  [PubMed]
  93 267 -
CORRESPONDENCES
Research oriented medical education in India
S Aggarwal
April 2010, 131(4):590-590
PMID:20424315
Full text not available  [PDF]  [PubMed]
  113 245 -
ORIGINAL ARTICLES
Serum C3d levels in tropical pulmonary eosinophilia
D Ray, S Subramanyam, S Hari Krishna, VD Ramanathan
April 2010, 131(4):555-558
PMID:20424307
Full text not available  [PDF]  [PubMed]
  113 217 -
CORRESPONDENCES
Incomplete reporting of research in press releases : et tu, WHO?
J Puliyel, JL Mathew, R Priya
April 2010, 131(4):588-589
PMID:20424314
Full text not available  [PDF]  [PubMed]
  115 205 -
COMMENTARIES
Genome-based diagnosis of genetic disease
Ching- Wan Lam
April 2010, 131(4):484-485
PMID:20424298
Full text not available  [PDF]  [PubMed]
  117 174 -
CORRESPONDENCES
Scoring more than ten plus century - Antiquity in gerontology?
Jitendra Kumar Sinha, S Ghosh
April 2010, 131(4):586-587
PMID:20424313
Full text not available  [PDF]  [PubMed]
  84 171 -
EDITORIALS
Counting malaria out - what progress?
Nilanthi de Silva, R Wickremasinghe
April 2010, 131(4):475-477
PMID:20424295
Full text not available  [PDF]  [PubMed]
  79 164 -
ANNOUNCEMENTS
Announcements

April 2010, 131(4):595-595
Full text not available  [PDF]
  82 97 -
BOOK REVIEWS
Book Reviews

April 2010, 131(4):591-593
Full text not available  [PDF]
  76 82 -
SOME FORTHCOMING SCIENTIFIC EVENTS
Some forthcoming scientific events

April 2010, 131(4):594-594
Full text not available  [PDF]
  75 77 -
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