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   2009| May  | Volume 129 | Issue 5  
    Online since April 20, 2011

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Diet & insulin resistance : a review & Asian Indian perspective
S Isharwal, A Misra, JS Wasir, P Nigam
May 2009, 129(5):485-499
Insulin resistance is associated with type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). These abnormalities have been aggravated because of imbalanced and excess nutrition in developed countries, and rapid nutritional and lifestyle transition occurring in developing countries. This review presents evidence linking dietary nutrients with insulin resistance and its metabolic correlates, and also describes these issues from a Asian Indians and South Asian perspective. Despite possible influences from genetic and perinatal factors, diet and physical activity are likely to have greater and often overriding influence in pathogenesis of the insulin resistance, the metabolic syndrome, and T2DM. In animal studies, a link has been established between dietary nutrients and insulin resistance. However, in human studies evidence is not as strong as in animals. Data suggest that dietary omega-3 polyunsaturated fatty acids (PUFAs) improve lipid profile and may have beneficial effect on insulin resistance. Dietary saturated fatty acids intake is positively associated with insulin resistance. Also, low glycaemic index foods and whole grain intake decrease insulin resistance. Importantly, high carbohydrate diets increase plasma triglycerides, cause hyperinsulinaemia and decreases low-density lipoprotein cholesterol. Among micronutrients, high magnesium and calcium intake have been reported to decrease insulin resistance. High intake of dietary carbohydrate and omega-6 PUFAs, low intake of omega-3 PUFAs and fiber, and high omega -6/omega-3 PUFAs ratio have been reported in South Asians. Our recent investigations have shown that increased dietary omega-6 PUFAs and saturated fat intake are significantly associated with fasting hyperinsulinaemia and sub-clinical inflammation, respectively. Such imbalanced diets contribute to high prevalence of insulin resistance, the metabolic syndrome and T2DM in South Asians and Asian Indians.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  277 195 -
Hepatoprotective activity of six polyherbal formulations in paracetamol induced liver toxicity in mice
C Girish, BC Koner, S Jayanthi, KR Rao, B Rajesh, SC Pradhan
May 2009, 129(5):569-578
Full text not available  [PDF]  [PubMed]
  191 194 -
Effects of resistance training on metabolic profile of adults with type 2 diabetes
E Arora, S Shenoy, JS Sandhu
May 2009, 129(5):515-519
Full text not available  [PDF]  [PubMed]
  207 171 -
In vitro interference of Hyptis martiusii Benth. & chlorpromazine against an aminoglycoside-resistant Escherichia coli
Henrique D.M. Coutinho, José G.M. Costa, Edeltrudes O Lima, Vivyanne S Falcăo-Silva, José P Siqueira-Júnior
May 2009, 129(5):566-568
The antibacterial and synergistic activity of the ethanol extract from Hyptis martiusii Benth. was assayed by microdillution. The growth of two isolates of Escherichia coli tested was inhibited by the extract. The minimum inhibitory and minimum bactericidal concentrations (MIC and MBC) values ranged from 512 and >1024 microg/ml for the E. coli 27 and 1024 and > 1024 microg/ml for the E. coli ATCC8539, respectively. A synergism between this extract and all aminoglycosides assayed was demonstrated. In the same form synergism between chlorpromazine and kanamycin, amikacin and tobramycin was observed, indicating the involvement of an efflux system. Extracts from H. martiusii could be used as a source of plant derived natural products with modifying antibiotic activity and these products may interact and affect multidrug resistance systems (MDR) as efflux pumps.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  207 100 -
Effects of progressive muscular relaxation training on quality of life in anxious patients after coronary artery bypass graft surgery
T Dehdari, A Heidarnia, A Ramezankhani, S Sadeghian, F Ghofranipour
May 2009, 129(5):603-608
Full text not available  [PDF]  [PubMed]
  149 158 -
Epidemiology & antibiograms of Vibrio cholerae isolates from a tertiary care hospital in Chandigarh, north India
J Chander, N Kaistha, V Gupta, M Mehta, N Singla, A Deep, BL Sarkar
May 2009, 129(5):613-617
Full text not available  [PDF]  [PubMed]
  100 193 -
Influenza A (H1N1) : responding to a pandemic threat
Jai P Narain, R Bhatia
May 2009, 129(5):465-467
Full text not available  [PDF]  [PubMed]
  130 135 -
Application of SNaPshot for analysis of thiopurine methyltransferase gene polymorphism
G Kapoor, A Maitra, Somlata , V Brahmachari
May 2009, 129(5):500-505
Full text not available  [PDF]  [PubMed]
  125 134 -
Influenza a virus induced apoptosis : inhibition of DNA laddering & caspase-3 activity by zinc supplementation in cultured HeLa cells
V Srivastava, S Rawall, VK Vijayan, M Khanna
May 2009, 129(5):579-586
Full text not available  [PDF]  [PubMed]
  108 145 -
In vitro effect of fluoroquinolones against Mycobacterium tuberculosis isolates from Agra & Kanpur region of north India
M Singh, DS Chauhan, P Gupta, R Das, RK Srivastava, P Upadhyay, P Singh, K Srivastava, J Faujdar, G.P.S. Jaudaun, VS Yadav, VD Sharma, K Venkatesan, S Sachan, P Sachan, K Katoch, VM Katoch
May 2009, 129(5):542-547
Full text not available  [PDF]  [PubMed]
  145 107 -
Pictorial health warnings are a must for effective tobacco control
K Srinath Reddy, M Arora
May 2009, 129(5):468-471
Full text not available  [PDF]  [PubMed]
  96 151 -
Predictors of metabolic syndrome in Asian north Indians with newly detected type 2 diabetes
E Dhanaraj, A Bhansali, S Jaggi, P Dutta, S Jain, P Tiwari, P Ramarao
May 2009, 129(5):506-514
Full text not available  [PDF]  [PubMed]
  107 109 -
Methodology for surveillance of antimicrobials use among out-patients in Delhi
A Kotwani, K Holloway, RR Chaudhury
May 2009, 129(5):555-560
Full text not available  [PDF]  [PubMed]
  110 104 -
Faecal carriage of CTX-M-15-producing Klebsiella pneumoniae in patients with acute gastroenteritis
Muzaheed , Y Doi, JM Adams-Haduch, CT Shivannavar, DL Paterson, SM Gaddad
May 2009, 129(5):599-602
Full text not available  [PDF]  [PubMed]
  97 113 -
Anti-hyperglycaemic potential of Psidium guajava raw fruit peel
Prashant K Rai, D Jaiswal, S Mehta, G Watal
May 2009, 129(5):561-565
Full text not available  [PDF]  [PubMed]
  111 90 -
Impact of etofenprox (Vectron® 20 WP) indoor residual spray on malaria transmission
U Sreehari, PK Mittal, RK Razdan, AP Dash, MA Ansari
May 2009, 129(5):593-598
Full text not available  [PDF]  [PubMed]
  102 92 -
Prolonged constriction of sciatic nerve affecting oxidative stressors & antioxidant enzymes in rat
D Varija, KP Kumar, KP Reddy, VK Reddy
May 2009, 129(5):587-592
Full text not available  [PDF]  [PubMed]
  98 91 -
Incomplete immunological recovery following anti-tuberculosis treatment in HIV-infected individuals with active tuberculosis
LE Hanna, K Nayak, S Subramanyam, P Venkatesan, PR Narayanan, S Swaminathan
May 2009, 129(5):548-554
Full text not available  [PDF]  [PubMed]
  91 96 -
In silico characterization of genetic homology in nuclear-encoded apicoplast-targeted genes between Plasmodium falciparum & P. vivax
S Mohanty, S Saklani, M Mahajan
May 2009, 129(5):520-524
Full text not available  [PDF]  [PubMed]
  100 87 -
Metabolic syndrome as a marker of risk in type 2 diabetes
R Gupta
May 2009, 129(5):481-484
Full text not available  [PDF]  [PubMed]
  101 85 -
The Cambridge textbook of bioethics
GD Ravindran
May 2009, 129(5):620-621
Full text not available  [PDF]
  101 83 -
Salt never calls itself sweet
Ragavendra R Baliga, J Narula
May 2009, 129(5):472-477
Full text not available  [PDF]  [PubMed]
  73 111 -
TPMT gene polymorphisms : on the doorstep of personalized medicine
S Pavlovic
May 2009, 129(5):478-480
Full text not available  [PDF]  [PubMed]
  93 83 -
Challenges of introducing vaginal microbicides in India
S Joshi, V Kulkarni, R Paranjape, N Chandhiok
May 2009, 129(5):618-619
Full text not available  [PDF]  [PubMed]
  77 95 -
Identification of novel variants in the COL4A4 gene in Korean patients with thin basement membrane nephropathy
JI Baek, SJ Choi, SH Park, JY Choi, CD Kim, YL Kim, UK Kim
May 2009, 129(5):525-533
Full text not available  [PDF]  [PubMed]
  78 94 -
Characterization & evolutionary analysis of human CD36 gene
G Awasthi, Aditya P Dash, A Das
May 2009, 129(5):534-541
Full text not available  [PDF]  [PubMed]
  80 83 -

May 2009, 129(5):623-623
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  72 83 -
Some Forthcoming Scientific Events

May 2009, 129(5):622-623
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  62 71 -
Plasma paraoxonase activity in patients with systemic sclerosis
IB Erguder, S Erten, E Devrim, M Turgay, I Durak
May 2009, 129(5):609-612
Full text not available     [PubMed]
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