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   2009| January  | Volume 129 | Issue 1  
    Online since April 20, 2011

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Animal models of tuberculosis for vaccine development
UD Gupta, VM Katoch
January 2009, 129(1):11-18
Animal models for testing different vaccine candidates have been developed since a long time for studying tuberculosis. Mice, guinea pigs and rabbits are animals most frequently used. Each model has its own merits for studying human tuberculosis, and none completely mimics the human disease. Different animal models are being used depending upon the availability of the space, trained manpower as well as other resources. Efforts should continue to develop a vaccine which can replace/outperform the presently available vaccine BCG.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  350 133 -
An increase in enteric fever cases due to Salmonella Paratyphi A in & around Chandigarh
V Gupta, J Kaur, J Chander
January 2009, 129(1):95-98
Full text not available  [PDF]  [PubMed]
  115 364 -
Ectopic Cushing's syndrome : experience from a tertiary care centre
A Bhansali, R Walia, SS Rana, P Dutta, BD Radotra, N Khandelwal, SK Bhadada
January 2009, 129(1):33-41
Full text not available  [PDF]  [PubMed]
  201 260 -
Informed consent & ethical issues in paediatric psychopharmacology
S Malhotra, BN Subodh
January 2009, 129(1):19-32
Issues relating to informed consent and ethics in paediatric psychopharmacology limit research in this population. Children vary in their levels of cognitive development, and presence of psychiatric disorder may further impair their ability to give informed consent. In decisional impairment subjects, various methods used for consent are assent/dissent; inclusion of advance directives; and/or alternative decision-makers. India is emerging as a new market for clinical trials in recent years. Moreover, in India the sociocultural realities are different from those in the western countries making it necessary for professionals to be cautious in conducting drug trials. In this review, issues regarding informed consent in children and adolescent with psychiatric diagnosis are discussed for information, discussion and debate by professionals, parents, society and legal experts to create awareness and to facilitate development of guidelines that are appropriate and applicable to the Indian system.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  311 132 -
Establishment of T-lymphocyte subset reference intervals in a healthy adult population in Chennai, India
KG Murugavel, P Balakrishnan, J Mohanakrishnan, SS Solomon, EM Shankar, Sandeep Pulimi Muthu Sundaram, N Kumarasamy, E Piwowar-Manning, E Livant, KH Mayer, SP Thyagarajan, S Solomon
January 2009, 129(1):59-63
Estimation of CD4+ T-lymphocytes continues to be an important aspect for monitoring HIV disease progression and response to antiretroviral therapy. Most of the diagnostic laboratories often rely on western text books for CD4+ T-lymphocyte reference values, which could, often be unreliable for usage in local settings. Therefore, we attempted to establish the reference values for T-lymphocyte subsets among healthy adults in a cross-sectional study carried out at the YRG Centre for AIDS Research and Education (YRG CARE) in Chennai, south India, in 213 (84 female and 129 male) healthy, HIV-1/2 seronegative adults as volunteers. Whole blood specimens were processed for CD4+, CD8+ T-lymphocyte estimation and haematological parameters. The established range of CD4+ T-lymphocyte counts for men and women were 383-1347 cells/microl (mean 865 and median 845 cells/microl) and 448-1593 cells/microl (mean 1021 and median 954 cells/microl), respectively. Women had significantly higher absolute CD4+ Tlymphocyte counts (P<0.001) and CD4+:CD8+ T-lymphocyte ratio as compared to men. The established normal range of CD4+ T-lymphocyte % was 21-59 (mean 40.2 and median 40.1). The influence of age was not observed in any of the parameters except CD4+/CD8+ T-lymphocyte ratio with the >45 yr age group. Further studies with greater sample size may be required to define the staging of HIV disease in relation to the normal CD4 T-lymphocyte count in the general population.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  320 115 -
Improved estimates of India's HIV burden in 2006
A Pandey, Dandu C Reddy, Peter D Ghys, M Thomas, D Sahu, M Bhattacharya, Kanchan D Maiti, F Arnold, S Kant, A Khera, R Garg
January 2009, 129(1):50-58
Full text not available  [PDF]  [PubMed]
  162 215 -
Role of acute viral hepatitis as a confounding factor in antituberculosis treatment induced hepatotoxicity
P Sarda, SK Sharma, A Mohan, G Makharia, A Jayaswal, RM Pandey, S Singh
January 2009, 129(1):64-67
Full text not available  [PDF]  [PubMed]
  180 142 -
An exploratory clinical study of adult attention deficit/hyperactivity disorder from India
P Sitholey, V Agarwal, S Sharma
January 2009, 129(1):83-88
Full text not available  [PDF]  [PubMed]
  135 180 -
Demographic & clinical profile of HIV infected children accessing care at Tambaram, Chennai, India
S Rajasekaran, L Jeyaseelan, K Raja, N Ravichandran
January 2009, 129(1):42-49
Full text not available  [PDF]  [PubMed]
  189 104 -
Addition of isovitalex in chocolate agar for the isolation of Haemophilus influenzae
SK Saha, AH Baqui, GL Darmstadt, M Islam, SE Arifeen, M Santosham, T Nagatake, RE Black
January 2009, 129(1):99-101
Full text not available  [PDF]  [PubMed]
  164 121 -
Newer strategies for the kala-azar elimination programme in India
CP Thakur, Amit Kumar Meenakshi Thakur, S Thakur
January 2009, 129(1):102-104
Full text not available  [PDF]  [PubMed]
  141 122 -
Systemic manifestations in chronic arsenic toxicity in absence of skin lesions in West Bengal
KK Majumdar, DN Guha Mazumder, N Ghose, A Ghose, S Lahiri
January 2009, 129(1):75-82
Full text not available  [PDF]  [PubMed]
  119 129 -
Shift to Th2 cytokine response in dengue haemorrhagic fever
UC Chaturvedi
January 2009, 129(1):1-3
Full text not available  [PDF]  [PubMed]
  123 120 -
Challenges in providing HIV care to paediatric age group in India
P Haldar, DC S Reddy
January 2009, 129(1):7-10
Full text not available  [PDF]  [PubMed]
  138 101 -
PCR on formalin-fixed necropsy tissues to diagnose leptospirosis
V Manu, S Roy, Anita R DuttaRoy, S Sharma, P Vijayachari, VK Kataria, SC Seghal
January 2009, 129(1):105-107
Full text not available  [PDF]  [PubMed]
  139 97 -
Association of mutations in rpsL gene with high degree of streptomycin resistance in clinical isolates of Mycobacterium tuberculosis in India
R Das, P Gupta, P Singh, DS Chauhan, K Katoch, VM Katoch
January 2009, 129(1):108-110
Full text not available  [PDF]  [PubMed]
  123 110 -
Ectopic Cushing's syndrome : some facts
R Salvatori
January 2009, 129(1):4-6
Full text not available  [PDF]  [PubMed]
  111 119 -
Murine monoclonal anti-H as typing reagent
YS Iyer, K Vasantha, V Pujari, S Jadhav, K Ghosh
January 2009, 129(1):72-74
Full text not available  [PDF]  [PubMed]
  114 99 -
Monitoring and evaluation of mental health policies and plans
Shridhar Sharma
January 2009, 129(1):111-112
Full text not available  [PDF]
  123 80 -
Endothelial nitric oxide synthase (eNOS) Glu298-->Asp polymorphism (G894T) among south Indians
NS Nishevitha, T Angeline, N Jeyaraj
January 2009, 129(1):68-71
Full text not available  [PDF]  [PubMed]
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Some Forthcoming Scientific Events

January 2009, 129(1):115-115
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  93 92 -
Evaluation of certain food additives and contaminants
Kalpgam Polasa
January 2009, 129(1):112-114
Full text not available  [PDF]
  99 76 -
Book Received

January 2009, 129(1):114-114
Full text not available  [PDF]
  95 67 -
Expression of class III β-tubulin in colorectal carcinomas : an immunohistochemical study using TU-20 & TuJ-1 antibody.
T Jirásek, Š Cipro, A Musilová, M Kubecová, V Mandys
January 2009, 129(1):89-94
Full text not available  [PDF]  [PubMed]
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January 2009, 129(1):115-115
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