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   2008| June  | Volume 127 | Issue 6  
    Online since May 11, 2011

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Correlates of overweight & obesity among school going children of Wardha city, Central India
DR Bharati, PR Deshmukh, BS Garg
June 2008, 127(6):539-543
Full text not available  [PDF]  [PubMed]
  106 403 -
Behavioural risk factors for non communicable diseases among adults in Kerala, India
TN Sugathan, CR Soman, K Sankaranarayanan
June 2008, 127(6):555-563
Full text not available  [PDF]  [PubMed]
  167 228 -
Resurgence of diphtheria in Malegaon & Dhule regions of north Maharashtra
MN Dravid, SA Joshi
June 2008, 127(6):616-617
Full text not available  [PDF]  [PubMed]
  158 226 -
Preparedness for AIDS vaccine trials in India
JL Excler, S Kochhar, S Kapoor, S Das, J Bahri, Meenakshi Datta Ghosh, NK Ganguly, A Nayyar, M Chataway
June 2008, 127(6):531-538
India bears a heavy disease burden of HIV/AIDS infected and affected people. A safe, effective and accessible preventive AIDS vaccine, used along with other preventive interventions, is urgently needed to stem the epidemic. This review highlights the extensive preparedness activities undertaken from 2002 by the International AIDS Vaccine Initiative (IAVI), its Indian government and non government partners with the Indian scientific, political, media and community stakeholders and the capacity building process, before the conduct of the first ever AIDS vaccine trials in India in early 2005. Issues addressed included mistrust of clinical research due to past history of some unethical trials, transparency, community involvement, stigma and discrimination, provision for care and treatment of participants, informed consent, gender considerations, approval process, and operational aspects. The strong political support along with preparedness activities led to the successful conduct of AIDS vaccine trials enrolling equitably healthy women and men from all sections of society. This has paved the way for future vaccine trials in the country.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  268 105 -
Genetic polymorphism of CYP2C19 & therapeutic response to proton pump inhibitors
AS Chaudhry, R Kochhar, KK Kohli
June 2008, 127(6):521-530
Proton pump inhibitors (PPIs) are extensively metabolized in the liver by CYP2C19, that demonstrates genetic polymorphism with 21 mutant alleles. The subjects can be divided into 2 groups with respect to CYP2C19 phenotypes viz., extensive metabolizers (EMs) and poor metabolizers (PMs) of PPIs. This division results in marked interindividual variations in the pharmacokinetics and pharmacodynamics of PPIs in the population. Intragastric pH values and the plasma concentration of PPIs after oral ingestion were significantly lower in EMs namely normal homozygotes (CYP2C19*1/*1) and heterozygotes (CYP2C19*1/*X) compared to PMs namely mutant homozygotes (CYP2C19*X/*X) where 'X' represents the mutant allele. Hence, association has been found between the genetic polymorphism of CYP2C19 and therapeutic response to PPIs. CYP2C19 polymorphism affected eradication of Helicobacter pylori using diferent PPI based eradication therapies as PM patients demonstrated significantly higher eradication rates compared to EMs. CYP2C19 genetic polymorphism also affects the therapeutic outcome of gastroesophageal reflux disease (GERD), reflux oesophagitis and duodenal ulcers. For optimal therapeutic response with PPIs, CYP2C19 pharmacogenetics should be taken into consideration. This shall help in the prescription of optimal doses of PPIs, thus paving the way for personalized medication.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  211 102 -
Effect of nicotine on lipid profile, peroxidation & antioxidant enzymes in female rats with restricted dietary protein
K Chattopadhyay, BD Chattopadhyay
June 2008, 127(6):571-576
Full text not available  [PDF]  [PubMed]
  114 166 -
Age composition of incriminated malaria vector in a rural foothills in West Bengal, India
G Chandra
June 2008, 127(6):607-609
Two 1 yr surveys carried out at a gap of 10 yr revealed nine anopheline species from malaria endemic foothills area of Ayodhya - Baghmindi range of West Bengal, India, with 8.4 per cent populations of Anopheles culicifacies. An. culicifacies was incriminated as vector of Plasmodium falciparum with sporozoite rate of 1.23 per cent. Studies on age composition indicated that proportion parous and daily survival rate of An. culicifacies were assessed to be 0.50 and 0.84 respectively. The survival rate per gonotrophic cycle averaged over the two year was 0.61. Rainy season was found to be the favourable period for transmission.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  188 91 -
Shigellosis in Puducherry
R Dhodapkar, N Srinivas Acharya, BN Harish, SC Parija
June 2008, 127(6):621-622
Full text not available  [PDF]  [PubMed]
  110 142 -
Pre-operative intravenous fluid therapy with crystalloids or colloids on post-operative nausea & vomiting
S Chaudhary, AK Sethi, P Motiani, C Adatia
June 2008, 127(6):577-581
Full text not available  [PDF]  [PubMed]
  117 131 -
Prevention of childhood obesity should be an integral part of prevention of non communicable diseases
A Ramachandran, C Snehalatha
June 2008, 127(6):514-515
Full text not available  [PDF]  [PubMed]
  121 122 -
Molecular characterization of shiga like toxin-producing Escherichia coli (STEC) isolates from pigs oedema
NN Barman, R Deb, T Ramamurthy, RK Sharma, P Borah, SA Wani, D Kalita
June 2008, 127(6):602-606
Full text not available  [PDF]  [PubMed]
  117 102 -
Anatomy & distribution of coronary arteries in pig in comparison with man
D Sahni, GD Kaur, H Jit, I Jit
June 2008, 127(6):564-570
Full text not available  [PDF]  [PubMed]
  113 99 -
Spread, establishment & prevalence of dengue vector Aedes aegypti (L.) in Konkan region, Maharashtra, India
PV Fulmali, A Walimbe, PV Mahadev
June 2008, 127(6):589-601
Full text not available  [PDF]  [PubMed]
  98 110 -
Characterisation of depression in patients with schizophrenia
A Heald, J Morris, Som D Soni
June 2008, 127(6):544-550
Full text not available  [PDF]  [PubMed]
  109 97 -
Symptoms of depression in schizophrenia
T Murali, S Ravi Kumar
June 2008, 127(6):516-518
Full text not available  [PDF]  [PubMed]
  103 97 -
The safety of rubella vaccine in pregnancy
T Jacob John
June 2008, 127(6):519-520
Full text not available  [PDF]  [PubMed]
  109 87 -
Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells
Ya Zhen Shang, Bo Wen Qin, Jian Jun Cheng, H Miao
June 2008, 127(6):610-615
Full text not available  [PDF]  [PubMed]
  96 83 -
Comparison of treatment regimens of kala-azar based on culture & sensitivity of amastigotes to sodium antimony gluconate
CP Thakur, S Thakur, S Narayan, A Sinha
June 2008, 127(6):582-588
Full text not available  [PDF]  [PubMed]
  87 88 -
Infiltration of Aedes aegypti into peri-urban areas in South Andaman
AN Shriram, AP Sugunan, P Vijayachari
June 2008, 127(6):618-620
Full text not available  [PDF]  [PubMed]
  93 78 -
HPV vaccine : end to women's major health problem?
K Somasundaram
June 2008, 127(6):511-513
Full text not available  [PDF]  [PubMed]
  64 91 -
Protecting health in Europe from climate change

June 2008, 127(6):624-624
Full text not available  [PDF]
  55 86 -
Public notice

June 2008, 127(6):626-626
Full text not available  [PDF]
  55 78 -
Some forthcoming scientific events

June 2008, 127(6):623-623
Full text not available  [PDF]
  53 70 -

June 2008, 127(6):625-625
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  54 63 -
Congenital rubella syndrome in infants of women vaccinated during or just before pregnancy with measles-rubella vaccine
Mohammad H Namaei, M Ziaee, N Naseh
June 2008, 127(6):551-554
Full text not available     [PubMed]
  99 0 -