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   2006| August  | Volume 124 | Issue 2  
    Online since May 20, 2011

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The requirements of protein & amino acid during acute & chronic infections
Anura V Kurpad
August 2006, 124(2):129-148
Nutrition and infection interact with each other in a synergistic vicious cycle, leading to an adverse nutritional status and increased susceptibility to infection. Infectious episodes result in hypermetabolism and a negative nitrogen balance which is modulated by hormones, cytokines and other pro-inflammatory mediators, and is compounded by a reduced food intake. The extent of the negative nitrogen balance varies with the type of infection and its duration; however, it is reasonable to suggest that the loss of body protein could be minimized by the provision of dietary nitrogen, although anorexia will limit this. Further, distinctions need to be made about the provision of nutrients or protein during the catabolic and anabolic or recovery phase of the infection, since the capacity of the body to retain protein is enhanced in the anabolic recovery phase. Meeting the increased requirement for protein (and other nutrients) in infection does not imply a complete therapeutic strategy. Infections need to be treated appropriately, with nutrition as an adjunct to the treatment. Prior undernutrition could also impair the body's response to infection, although the weight of the evidence would suggest that this happens more particularly in oedematous undernutrition. In general, the amount of extra protein that would appear to be needed is of the order of 20-25 per cent of the recommended intake, for most infections. In acute infections, this is particularly relevant during the convalescence period. Community trials have suggested that lysine supplementation to the level required for normal daily nutriture, in predominantly wheat eating or potentially lysine deficient communities, improves immune function among other functional nutritional parameters; however, there is as yet insufficient evidence to suggest a specific requirement for amino acids in infections over and above the normal daily requirement as based on recent evidence. Some clinical studies that have showed benefits with specific amino acids through selected clinical outcomes, however, these do not provide enough evidence for a firm recommendation.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  406 174 -
Neuroleptospirosis - revisited : experience from a tertiary care neurological centre from south India
T Mathew, P Satishchandra, A Mahadevan, S Nagarathna, TC Yasha, A Chandramukhi, DK Subbakrishna, SK Shankar
August 2006, 124(2):155-162
Full text not available  [PDF]  [PubMed]
  287 291 -
A random sample survey for prevalence of major neurological disorders in Kolkata
SK Das, A Biswas, T Roy, TK Banerjee, CS Mukherjee, DK Raut, A Chaudhuri
August 2006, 124(2):163-172
Full text not available  [PDF]  [PubMed]
  250 287 -
Prevalence of anaemia in pregnant & lactating women in India
KN Agarwal, DK Agarwal, A Sharma, K Sharma, K Prasad, MC Kalita, N Khetarpaul, AC Kapoor, L Vijayalekshmi, AK Govilla, SM Panda, P Kumari
August 2006, 124(2):173-184
Full text not available  [PDF]  [PubMed]
  216 235 -
Neuroleptospirosis : unexplored & overlooked
Alexandre Leite de Souza
August 2006, 124(2):125-128
Full text not available  [PDF]  [PubMed]
  209 142 -
Computer aided decision system for early detection of breast cancer
HS Sheshadri, A Kandaswamy
August 2006, 124(2):149-154
Full text not available  [PDF]  [PubMed]
  190 125 -
Pharyngeal carriage of group A streptococci in school children in Chennai
Charmaine A Lloyd, Swarna E Jacob, T Menon
August 2006, 124(2):195-198
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  176 129 -
The effect of Panax ginseng on forced immobility time & immune function in mice
HY Shin, HJ Jeong, Hyo-Jin-An , SH Hong, JY Um, TY Shin, SJ Kwon, SY Jee, BI Seo, SS Shin, DC Yang, HM Kim
August 2006, 124(2):199-206
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  152 147 -
Multidrug resistance in amoebiasis patients
D Bansal, R Sehgal, Y Chawla, N Malla, RC Mahajan
August 2006, 124(2):189-194
Full text not available  [PDF]  [PubMed]
  172 127 -
History of medicine: prehistoric to present
Sunil Pandya
August 2006, 124(2):216-217
Full text not available  [PDF]
  136 143 -
Computer-aided diagnosis : radiologists' "second opinion" in breast cancer diagnosis on mammography
C Zhou
August 2006, 124(2):123-124
Full text not available  [PDF]  [PubMed]
  158 111 -
Rising rates of caesarean section : the way ahead
A Oumachigui
August 2006, 124(2):119-122
Full text not available  [PDF]  [PubMed]
  131 133 -
Prevalence of proteinuria in rural adult population in Tamil Nadu
I Ahmed, George T John, Meshach G Kirubakaran, Chakko K Jacob, J Muliyil
August 2006, 124(2):185-188
Full text not available  [PDF]  [PubMed]
  144 115 -
Cervical cancer screening in developing countries
BC Das, A Sehgal
August 2006, 124(2):215-216
Full text not available  [PDF]
  147 107 -
Seroprevalence of Japanese encephalitis virus infection in Lucknow, Uttar Pradesh
A Roy, R Tandon, SK Agarwal, G Banerjee
August 2006, 124(2):211-212
Full text not available  [PDF]  [PubMed]
  116 113 -
From population control to reproductive health: Malthusian arithmetic
Ashish Bose
August 2006, 124(2):213-214
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  108 99 -
Some forthcoming scientific events

August 2006, 124(2):218-219
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  113 79 -

August 2006, 124(2):220-220
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  74 82 -
Reduced antioxidant potential & sensitivity to oxidation in plasma low density lipoprotein fraction in type 2 diabetes mellitus patients
Imge B Ergüder, N Karagenç, L Karaca
August 2006, 124(2):207-210
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  42 58 -