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2009| February | Volume 129 | Issue 2
Online since
April 20, 2011
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REVIEW ARTICLE
Role of reactive oxygen species in the pathogenesis of mitochondrial DNA (mtDNA) mutations in male infertility
S Venkatesh, M Deecaraman, R Kumar, MB Shamsi, R Dada
February 2009, 129(2):127-137
PMID
:19293438
Infertility affects about 15 per cent married couples half of which may be attributed to men with low sperm motility (asthenozoospermia), low sperm count (oligozoospermia) or abnormal sperm morphology (teratozoospermia). As mitochondria are the energy source for initiation, differentiation and function of the germ cells, mutation in mitochondrial genome can impair the formation of mature spermatozoa. Mutations in mitochondrial genome are identified in patients with fertility problems. However, mitochondria are also both the source and target of reactive oxygen species (ROS). ROS are normally generated at low levels by human spermatozoa in order to perform its physiological function. However, if the generation of these reactive free radicals overwhelm the antioxidant defense system, this can lead to oxidative stress, which is characterized by mitochondrial and nuclear genome damage. So both ROS and mtDNA mutations are considered to be the major aetiological factors in a variety of human diseases including male infertility. Identification of novel mutations in mtDNA of infertile patients with supraphysiological levels of ROS are considered to be important to gain better understanding of the aetiology of idiopathic infertility. Early detection and prompt antioxidant therapy can prevent ROS induced DNA damage. This has far reaching impact if such men opt for assisted reproductive technology (ART)/in vitro fertilization.
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ORIGINAL ARTICLES
Application of 16S rDNA based seminested PCR for diagnosis of acute bacterial meningitis
P Chakrabarti, BK Das, A Kapil
February 2009, 129(2):182-188
PMID
:19293446
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Influence of squalene feeding on plasma leptin, testosterone & blood pressure in rats
Y Liu, X Xu, D Bi, X Wang, X Zhang, H Dai, S Chen, W Zhang
February 2009, 129(2):150-153
PMID
:19293441
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Body composition & cardiovascular functions in healthy males acclimatized to desert & high altitude
Amitabh , VK Singh, P Vats, S Kishnani, SN Pramanik, SN Singh, Shashi Bala Singh, PK Banerjee
February 2009, 129(2):138-143
PMID
:19293439
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Biochemical analysis of protein stability in human brain collected at different post-mortem intervals
R Chandana, RB Mythri, A Mahadevan, SK Shankar, MM Srinivas Bharath
February 2009, 129(2):189-199
PMID
:19293447
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CORRESPONDENCES
Antipsychotic drugs & their side effects
R Jaco
February 2009, 129(2):208-209
PMID
:19293453
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COMMENTARIES
Placental pathology in thrombophilia : establishing clinico-pathological correlations
N Marwaha
February 2009, 129(2):123-125
PMID
:19293437
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EDITORIAL
Commission on Social Determinants in Health : A piece meal move?
KR Nayar, Sonali Sahni Kapoor
February 2009, 129(2):117-119
PMID
:19293435
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CORRESPONDENCES
Authors' response
S Minz, V Balraj, MK Lalitha, N Murali, T Cherian, G Manoharan, S Kadirvan, A Joseph, MC Steinhoff
February 2009, 129(2):206-207
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Equitable healthcare & access to affordable medicines in India
MD Janodia, D Sreedhar, VS Ligade, S Pandey, N Udupa
February 2009, 129(2):200-200
PMID
:19293448
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ORIGINAL ARTICLES
DNA sequencing by Microseq kit targeting 16S rRNA gene for species level identification of mycobacteria
K Lily Therese, J Bartell, P Deepa, S Mangaiyarkarasi, D Ward, J Dajcs, HN Madhavan, D Stroman
February 2009, 129(2):176-181
PMID
:19293445
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Placental histomorphology in unexplained foetal loss with thrombophilia
S Vora, S Shetty, M Khare, K Ghosh
February 2009, 129(2):144-149
PMID
:19293440
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COMMENTARIES
The need for longitudinal measurements at altitude
AV Kurpad
February 2009, 129(2):120-122
PMID
:19293436
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CORRESPONDENCES
Malaria - change in therapeutic policy
PK Kar, RM Bhatt, A Anvikar, VK Dua
February 2009, 129(2):203-204
PMID
:19293450
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ORIGINAL ARTICLES
Organic anion transporter protein (OATP1B1) encoded by SLCO1B1 gene polymorphism (388A>G) & susceptibility in gallstone disease
C Jindal, S Kumar, G Choudhari, H Goel, B Mittal
February 2009, 129(2):170-175
PMID
:19293444
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Effects of hypoxia inducible factor-1α (HIF-1α) on the growth & adhesion in tongue squamous cell carcinoma cells
Y Song, W Wang, X Qu, S Sun
February 2009, 129(2):154-163
PMID
:19293442
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BOOK REVIEW
WHO Expert Committee on specifications for pharmaceutical preparations
SD Seth, Mohua Maulik
February 2009, 129(2):210-211
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ORIGINAL ARTICLES
Asymmetrical release of interleukin-6 by cultured cerebral cortical astrocytes treated with lipopolysaccharide
J Zhang, Y Gao, Y Shen, K Li
February 2009, 129(2):164-169
PMID
:19293443
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CORRESPONDENCES
WHO study suggests low incidence of Hib in india is due to natural immunity
N Gupta, J Puliyel
February 2009, 129(2):205-205
PMID
:19293451
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Reviving frogs in India's freshwater environment to control mosquito-borne diseases
G Agoramoorthy
February 2009, 129(2):201-202
PMID
:19293449
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Authors' response
S Singh, SK Mattoo
February 2009, 129(2):209-209
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ANNOUNCEMENT
Announcement
February 2009, 129(2):213-213
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SOME FORTHCOMING SCIENTIFIC EVENTS
Some Forthcoming Scientific Events
February 2009, 129(2):212-212
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FORM IV
Form IV
February 2009, 129(2):213-213
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© Indian Journal of Medical Research | Published by Wolters Kluwer -
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Online since 25 February, 2011