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2007| July | Volume 126 | Issue 1
Online since
May 20, 2011
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ORIGINAL ARTICLES
Comparative evaluation of smear cytology & hybrid capture II for the diagnosis of cervical cancer
K Kumar, Venkateswaran K Iyer, N Bhatla, A Kriplani, K Verma
July 2007, 126(1):39-44
PMID
:17890822
Full text not available
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[PubMed]
237
174
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BOOK REVIEWS
Protective effects of tea on human health
Kanwaljit Chopra
July 2007, 126(1):87-87
Full text not available
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166
196
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ORIGINAL ARTICLES
Association of mycobacteria with Eales' disease
KL Therese, P Deepa, J Therese, R Bagyalakshmi, J Biswas, HN Madhavan
July 2007, 126(1):56-62
PMID
:17890825
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[PubMed]
116
233
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Pre-tertiary hospital care of patients with chronic kidney disease in India
S Varughese, GT John, S Alexander, MN Deborah, N Nithya, I Ahamed, V Tamilarasi, CK Jacob
July 2007, 126(1):28-33
PMID
:17890820
Full text not available
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[PubMed]
126
193
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Toxoplasma seroprevalence in healthy voluntary blood donors from urban Karnataka
P Sundar, A Mahadevan, RS Jayshree, DK Subbakrishna, SK Shankar
July 2007, 126(1):50-55
PMID
:17890824
Full text not available
[PDF]
[PubMed]
145
161
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REVIEW ARTICLES
G-protein coupled receptors & autism -- reflections on a double-edged sword at the example of the oxytocin receptor system
Roy U Rojas Walh
July 2007, 126(1):13-21
PMID
:17890818
G-protein coupled receptors (GPCR) tend to desensitize/internalize when exposed to excess agonist.Previously, we have supported the argument that in the case of the oxytocin receptor (OTR), excess agonist (oxytocin, OT) at birth could be implicated with behavioural disorders of the autistic spectrum. In this review, more recent evidence for this hypothesis is summarized, and it is juxtaposed against reports where exogenous OT was found beneficial in alleviating certain undesired behaviours. Facing this dichotomy, we suggest possible in silico drug discovery approaches to mitigate undesired side effect of OT administration/OTR desensitization, especially in the light of potentially emerging agonist therapies. For this, the most important structural features of OTR are reviewed, and we highlight here the need for higher level of theory studies at the easier approachable extracellular receptor side, where loop 3(e3) and the N-terminated strain of OTR appear to offer targets of particular interest for the development of an agent that conditions the action of excess OT. Another approach, based on the development of new agonists with an improved receptor activation to receptor phosphorylation ratio, is also discussed. Finally, the issue of OTR desensitization is put into the broader context of GPCR desensitization and possible implications for behavioural disorders, and the case is made for the usefulness of computational studies in this area.
[ABSTRACT]
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[PubMed]
214
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ORIGINAL ARTICLES
Antibiotic resistance profile & extended spectrum beta-lactamase (ESBL) production in Acinetobacter species
M Sinha, H Srinivasa, R Macaden
July 2007, 126(1):63-67
PMID
:17890826
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[PubMed]
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Pharmacovigilance in kala-azar patients with severe thrombocytopenia caused by sodium antimony gluconate & miltefosine
CP Thakur, A Kumar, G Mitra, S Thakur, M Thakur
July 2007, 126(1):73-75
PMID
:17890828
Sodium antimony gluconate (SAG) and miltefosine used in the treatment of kala-azar are known to cause several side effects but severe thrombocytopenia has not been reported. Four cases of severe thrombocytopenia, two caused by SAG and two by miltefosine were promptly detected and treated by immediate withdrawal of the offending drugs, platelet and blood transfusions and dexamethasone. After improvement Leishman-Donovan (LD) bodies were demonstrated in splenic aspirates of both patients of SAG group and one of miltefosine and they were treated with 1 mg/kg body wt of amphotericin B for 20 days and cured. One patient of miltefosine group treated outside only on the basis of rK-39 positivity did not show LD bodies in splenic aspirates and improved without any antikala- azar drug. None of the patients relapsed within 6 months of follow up. Prompt detection of side effects under the concept of pharmacovigilance can save life of such patients.
[ABSTRACT]
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REVIEW ARTICLES
Factors affecting the expression of recombinant glycoproteins
M Devasahayam
July 2007, 126(1):22-27
PMID
:17890819
N-glycosylation is both species and tissue specific with a series of membrane bound glycosidases and glycosyltransferases modifying the oligosaccharide as it moves through the endoplasmic reticulum (ER) and Golgi. Each of these individual enzymatic reactions may not go to completion; therefore giving rise to glycoforms of the polypeptide. Glycosylation patterns of recombinant proteins are relevant for the immunogenicity, the pharmacological activity, pharmacokinetic profile, solubility and stability of the protein. This review describes the effect of primary and the 3-dimensional structure of the protein on sequon occupancy. Heterogeneity due to cell specific glycosylation and tissue culture conditions are discussed with main emphasis on N-glycosylation sequon occupancy. The review also discusses how fully glycosylated with total sequon occupancy glycoproteins which are of prime relevance in the expression of pharmaceutically relevant glycoproteins can be obtained.
[ABSTRACT]
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[PubMed]
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CORRESPONDENCES
Aerobic jejunal fluid bacteria in patients with gastrointestinal disorders
C Vaishnavi, S Singh, R Kochhar
July 2007, 126(1):76-78
PMID
:17890812
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[PubMed]
113
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ORIGINAL ARTICLES
Estrogen-like activity of volatile components from Vitex rotundifolia L
Y Hu, TT Hou, HL Xin, QY Zhang, HC Zheng, K Rahman, LP Qin
July 2007, 126(1):68-72
PMID
:17890827
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[PubMed]
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131
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COMMENTARIES
Chronic kidney disease in India--a hidden epidemic
M Rao, Brian J Pereira
July 2007, 126(1):6-9
PMID
:17890817
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[PubMed]
139
118
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EDITORIALS
Resurrection of DDT : a critical appraisal
AP Dash, K Raghavendra, MK Pillai
July 2007, 126(1):1-3
PMID
:17890815
Full text not available
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[PubMed]
131
102
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CORRESPONDENCES
Tracing transmission of tuberculosis by random amplified polymorphic DNA (RAPD) analysis within same family & neighbourhood
HB Singh, DS Chauhan, J Faujdar, P Upadhyay, N Saxena, VS Yadav, A Kumar, I Ahmed, VM Katoch, VD Sharma
July 2007, 126(1):82-84
PMID
:17890814
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[PubMed]
134
95
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COMMENTARIES
Clinical utility of antinuclear antibodies : titrating the serum first
A Wanchu
July 2007, 126(1):10-11
PMID
:17890811
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[PubMed]
116
86
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ORIGINAL ARTICLES
In vitro antimalarial activity of methylene blue against field isolates of Plasmodium falciparum from children in Southwest Nigeria
OG Ademowo, CM Nneji, AD Adedapo
July 2007, 126(1):45-49
PMID
:17890823
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[PubMed]
107
95
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CORRESPONDENCES
Abnormal serum pancreatic enzymes in an HIV infected child
I Shah
July 2007, 126(1):79-81
PMID
:17890813
Full text not available
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[PubMed]
91
91
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BOOK REVIEWS
Diagnostics for tuberculosis - Global demand and market potential
R Ramachandran
July 2007, 126(1):86-87
Full text not available
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83
93
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Health system performance assessment - World Health Survey– 2003 India
Ambujam Nair Kapur
July 2007, 126(1):85-85
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82
81
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EDITORIALS
We are surging ahead!
K Satyanarayana
July 2007, 126(1):4-5
Full text not available
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76
82
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ORIGINAL ARTICLES
Antinuclear antibodies by indirect immunofluorescence : optimum screening dilution for diagnosis of systemic lupus erythematosus
P Ghosh, S Dwivedi, S Naik, V Agarwal, A Verma, A Aggarwal, R Misra
July 2007, 126(1):34-38
PMID
:17890821
Full text not available
[PubMed]
146
0
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SOME FORTHCOMING SCIENTIFIC EVENTS
Some forthcoming scientific events
July 2007, 126(1):89-89
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61
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ANNOUNCEMENT
Announcement
July 2007, 126(1):88-88
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56
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BOOKS RECEIVED
Human embryology
July 2007, 126(1):87-87
Full text not available
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0
0
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Review of oral pathology (with explanatory answers)
July 2007, 126(1):87-87
Full text not available
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0
0
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ERRATUM
Erratum
July 2007, 126(1):88-88
Full text not available
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0
0
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Online since 25 February, 2011
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