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2006| November | Volume 124 | Issue 5
Online since
May 20, 2011
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CORRESPONDENCES
Skewed sex ratio in India
A Halder
November 2006, 124(5):583-584
PMID
:17213528
Full text not available
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[PubMed]
217
913
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ORIGINAL ARTICLES
Changing trends in sexually transmitted infections at a Regional STD Centre in north India
K Ray, M Bala, SM Gupta, N Khunger, P Puri, S Muralidhar, J Kumar
November 2006, 124(5):559-568
PMID
:17213525
Full text not available
[PDF]
[PubMed]
107
709
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REVIEW ARTICLE
Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine
SC Pradhan, C Girish
November 2006, 124(5):491-504
PMID
:17213517
Silymarin, a flavonolignan from 'milk thistle' (Silybum marianum) plant is used almost exclusively for hepatoprotection and amounts to 180 million US dollars business in Germany alone. In this review we discuss about its safety, efficacy and future uses in liver diseases. The use of silymarin may replace the polyherbal formulations and will avoid the major problems of standardization, quality control and contamination with heavy metals or bacterial toxins. Silymarin consists of four flavonolignan isomers namely--silybin, isosilybin, silydianin and silychristin. Among them, silybin being the most active and commonly used. Silymarin is orally absorbed and is excreted mainly through bile as sulphates and conjugates. Silymarin offers good protection in various toxic models of experimental liver diseases in laboratory animals. It acts by antioxidative, anti-lipid peroxidative, antifibrotic, anti-inflammatory, membrane stabilizing, immunomodulatory and liver regenerating mechanisms. Silymarin has clinical applications in alcoholic liver diseases, liver cirrhosis, Amanita mushroom poisoning, viral hepatitis, toxic and drug induced liver diseases and in diabetic patients. Though silymarin does not have antiviral properties against hepatitis virus, it promotes protein synthesis, helps in regenerating liver tissue, controls inflammation, enhances glucuronidation and protects against glutathione depletion. Silymarin may prove to be a useful drug for hepatoprotection in hepatobiliary diseases and in hepatotoxicity due to drugs. The non traditional use of silymarin may make a breakthrough as a new approach to protect other organs in addition to liver. As it is having a good safety profile, better patient tolerability and an effective drug at an affordable price, in near future new derivatives or new combinations of this drug may prove to be useful.
[ABSTRACT]
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[PubMed]
270
377
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CORRESPONDENCES
Fluoroquinolone resistance among Salmonella enterica serovar Paratyphi A in Pondicherry
BN Harish, GA Menezes, K Sarangapani, SC Parija
November 2006, 124(5):585-587
PMID
:17213529
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[PubMed]
110
359
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EDITORIALS
Vector biology of dengue & chikungunya viruses
DT Mourya, P Yadav
November 2006, 124(5):475-480
PMID
:17213513
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[PubMed]
99
260
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Chikungunya fever : clinical manifestations & management
A Mohan
November 2006, 124(5):471-474
PMID
:17213512
Full text not available
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[PubMed]
113
240
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CORRESPONDENCES
Antimicrobial resistance profile of Pseudomonas aeruginosa producing metallo-beta-lactamases
Vandana A Agarwal, Shruti A Dongre, Rajaram M Powar
November 2006, 124(5):588-590
PMID
:17213530
Full text not available
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[PubMed]
103
174
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EDITORIALS
Addressing the diabetes pandemic : a comprehensive approach
Mary Margaret Huizinga, Russell L Rothman
November 2006, 124(5):481-484
PMID
:17213514
Full text not available
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[PubMed]
96
144
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The curse of dengue
UC Chaturvedi
November 2006, 124(5):467-470
PMID
:17213511
Full text not available
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[PubMed]
100
127
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ORIGINAL ARTICLES
Feasibility of pre-operative autologous blood donation in Indian patients with elective orthopaedic surgery
K Saluja, N Marwaha, B Thakral, V Goni, RR Sharma, GD Puri
November 2006, 124(5):505-512
PMID
:17213518
Full text not available
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[PubMed]
119
100
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Injection practices in the formal & informal healthcare sectors in rural north India
M Kermode, V Muani
November 2006, 124(5):513-520
PMID
:17213519
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[PubMed]
80
130
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Effect of environmental iodine deficiency (EID) on foetal growth in Nigeria
SC Das, AZ Mohammed, S Al-Hassan, AA Otokwula, UP Isichei
November 2006, 124(5):535-544
PMID
:17213522
Full text not available
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[PubMed]
88
112
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Immune status of health care personnel & post vaccination analysis of immunity against rubella in an eye hospital
Thanapal Amala Rajasundari, K Chandrasekar, P Vijayalakshmi, V Muthukkaruppan
November 2006, 124(5):553-558
PMID
:17213524
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70
128
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COMMENTARIES
Protect the health of health care workers
T Jacob John
November 2006, 124(5):488-490
PMID
:17213516
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[PubMed]
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85
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ORIGINAL ARTICLES
Immunoreactive outer membrane proteins of Leptospira interrogans serovar Canicola strain Hond Utrecht IV
R Amutha, P Chaudhuri, Amar P Garg, PS Cheema, SK Srivastava
November 2006, 124(5):569-574
PMID
:17213526
Full text not available
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[PubMed]
86
102
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BOOK REVIEWS
Mental disorders in children and adolescents: Needs and strategies for intervention
Shoba Srinath
November 2006, 124(5):591-592
Full text not available
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74
97
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COMMENTARIES
Whither autologous blood predonations?
A Mijovic
November 2006, 124(5):485-487
PMID
:17213515
Full text not available
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[PubMed]
82
83
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ORIGINAL ARTICLES
Correlation between methotrexate efficacy & toxicity with C677T polymorphism of the methylenetetrahydrofolate gene in rheumatoid arthritis patients on folate supplementation
P Aggarwal, S Naik, KP Mishra, A Aggarwal, R Misra
November 2006, 124(5):521-526
PMID
:17213520
Full text not available
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[PubMed]
77
88
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Insulin resistance & secretion in subjects with normal fasting plasma glucose
CH Hsieh, YJ Hung, CZ Wu, SS Lee, CH Lee, CY Chen, JC Li, SW Kuo, KL Kuo, D Pei
November 2006, 124(5):527-534
PMID
:17213521
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80
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Assessment of mammographic density changes on plain film mammograms in postmenopausal women on hormone replacement therapy
S Orguc, C Goktan, Gulgun Yilmaz Ovali, O Karaer, S Oruc
November 2006, 124(5):545-552
PMID
:17213523
Full text not available
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[PubMed]
70
82
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Rapid detection of enterotoxigenic Bacteroides fragilis in diarrhoeal faecal samples
N Sharma, R Chaudhry
November 2006, 124(5):575-582
PMID
:17213527
Full text not available
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[PubMed]
66
84
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BOOK REVIEWS
The European health report 2005, Public health action for healthier children and populations
John Powles
November 2006, 124(5):592-593
Full text not available
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64
85
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SOME FORTHCOMING SCIENTIFIC EVENTS
Some forthcoming scientific events
November 2006, 124(5):594-595
Full text not available
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54
82
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ANNOUNCEMENTS
Announcements
November 2006, 124(5):596-596
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56
75
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Online since 25 February, 2011
Users Online: 2343
