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February 2009 Volume 129 | Issue 2
Page Nos. 117-213
Online since Wednesday, April 20, 2011
Accessed 4,944 times.
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EDITORIAL |
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Commission on Social Determinants in Health : A piece meal move? |
p. 117 |
KR Nayar, Sonali Sahni Kapoor PMID:19293435 |
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COMMENTARIES |
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The need for longitudinal measurements at altitude |
p. 120 |
AV Kurpad PMID:19293436 |
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Placental pathology in thrombophilia : establishing clinico-pathological correlations |
p. 123 |
N Marwaha PMID:19293437 |
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REVIEW ARTICLE |
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Role of reactive oxygen species in the pathogenesis of mitochondrial DNA (mtDNA) mutations in male infertility |
p. 127 |
S Venkatesh, M Deecaraman, R Kumar, MB Shamsi, R Dada PMID:19293438Infertility affects about 15 per cent married couples half of which may be attributed to men with low sperm motility (asthenozoospermia), low sperm count (oligozoospermia) or abnormal sperm morphology (teratozoospermia). As mitochondria are the energy source for initiation, differentiation and function of the germ cells, mutation in mitochondrial genome can impair the formation of mature spermatozoa. Mutations in mitochondrial genome are identified in patients with fertility problems. However, mitochondria are also both the source and target of reactive oxygen species (ROS). ROS are normally generated at low levels by human spermatozoa in order to perform its physiological function. However, if the generation of these reactive free radicals overwhelm the antioxidant defense system, this can lead to oxidative stress, which is characterized by mitochondrial and nuclear genome damage. So both ROS and mtDNA mutations are considered to be the major aetiological factors in a variety of human diseases including male infertility. Identification of novel mutations in mtDNA of infertile patients with supraphysiological levels of ROS are considered to be important to gain better understanding of the aetiology of idiopathic infertility. Early detection and prompt antioxidant therapy can prevent ROS induced DNA damage. This has far reaching impact if such men opt for assisted reproductive technology (ART)/in vitro fertilization. |
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ORIGINAL ARTICLES |
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Body composition & cardiovascular functions in healthy males acclimatized to desert & high altitude |
p. 138 |
Amitabh , VK Singh, P Vats, S Kishnani, SN Pramanik, SN Singh, Shashi Bala Singh, PK Banerjee PMID:19293439 |
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Placental histomorphology in unexplained foetal loss with thrombophilia |
p. 144 |
S Vora, S Shetty, M Khare, K Ghosh PMID:19293440 |
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Influence of squalene feeding on plasma leptin, testosterone & blood pressure in rats |
p. 150 |
Y Liu, X Xu, D Bi, X Wang, X Zhang, H Dai, S Chen, W Zhang PMID:19293441 |
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Effects of hypoxia inducible factor-1α (HIF-1α) on the growth & adhesion in tongue squamous cell carcinoma cells |
p. 154 |
Y Song, W Wang, X Qu, S Sun PMID:19293442 |
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Asymmetrical release of interleukin-6 by cultured cerebral cortical astrocytes treated with lipopolysaccharide |
p. 164 |
J Zhang, Y Gao, Y Shen, K Li PMID:19293443 |
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Organic anion transporter protein (OATP1B1) encoded by SLCO1B1 gene polymorphism (388A>G) & susceptibility in gallstone disease |
p. 170 |
C Jindal, S Kumar, G Choudhari, H Goel, B Mittal PMID:19293444 |
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DNA sequencing by Microseq kit targeting 16S rRNA gene for species level identification of mycobacteria |
p. 176 |
K Lily Therese, J Bartell, P Deepa, S Mangaiyarkarasi, D Ward, J Dajcs, HN Madhavan, D Stroman PMID:19293445 |
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Application of 16S rDNA based seminested PCR for diagnosis of acute bacterial meningitis |
p. 182 |
P Chakrabarti, BK Das, A Kapil PMID:19293446 |
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Biochemical analysis of protein stability in human brain collected at different post-mortem intervals |
p. 189 |
R Chandana, RB Mythri, A Mahadevan, SK Shankar, MM Srinivas Bharath PMID:19293447 |
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CORRESPONDENCES |
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Equitable healthcare & access to affordable medicines in India |
p. 200 |
MD Janodia, D Sreedhar, VS Ligade, S Pandey, N Udupa PMID:19293448 |
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Reviving frogs in India's freshwater environment to control mosquito-borne diseases |
p. 201 |
G Agoramoorthy PMID:19293449 |
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Malaria - change in therapeutic policy |
p. 203 |
PK Kar, RM Bhatt, A Anvikar, VK Dua PMID:19293450 |
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WHO study suggests low incidence of Hib in india is due to natural immunity |
p. 205 |
N Gupta, J Puliyel PMID:19293451 |
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Authors' response |
p. 206 |
S Minz, V Balraj, MK Lalitha, N Murali, T Cherian, G Manoharan, S Kadirvan, A Joseph, MC Steinhoff |
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Antipsychotic drugs & their side effects |
p. 208 |
R Jaco PMID:19293453 |
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Authors' response |
p. 209 |
S Singh, SK Mattoo |
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BOOK REVIEW |
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WHO Expert Committee on specifications for pharmaceutical preparations |
p. 210 |
SD Seth, Mohua Maulik |
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SOME FORTHCOMING SCIENTIFIC EVENTS |
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Some Forthcoming Scientific Events |
p. 212 |
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ANNOUNCEMENT |
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Announcement |
p. 213 |
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FORM IV |
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Form IV |
p. 213 |
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