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June 2008 Volume 127 | Issue 6
Page Nos. 511-626
Online since Wednesday, May 11, 2011
Accessed 6,415 times.
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EDITORIAL |
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HPV vaccine : end to women's major health problem? |
p. 511 |
K Somasundaram PMID:18765865 |
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COMMENTARIES |
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Prevention of childhood obesity should be an integral part of prevention of non communicable diseases |
p. 514 |
A Ramachandran, C Snehalatha PMID:18765866 |
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Symptoms of depression in schizophrenia |
p. 516 |
T Murali, S Ravi Kumar PMID:18765867 |
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The safety of rubella vaccine in pregnancy |
p. 519 |
T Jacob John PMID:18765868 |
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REVIEW ARTICLES |
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Genetic polymorphism of CYP2C19 & therapeutic response to proton pump inhibitors |
p. 521 |
AS Chaudhry, R Kochhar, KK Kohli PMID:18765869Proton pump inhibitors (PPIs) are extensively metabolized in the liver by CYP2C19, that demonstrates genetic polymorphism with 21 mutant alleles. The subjects can be divided into 2 groups with respect to CYP2C19 phenotypes viz., extensive metabolizers (EMs) and poor metabolizers (PMs) of PPIs. This division results in marked interindividual variations in the pharmacokinetics and pharmacodynamics of PPIs in the population. Intragastric pH values and the plasma concentration of PPIs after oral ingestion were significantly lower in EMs namely normal homozygotes (CYP2C19*1/*1) and heterozygotes (CYP2C19*1/*X) compared to PMs namely mutant homozygotes (CYP2C19*X/*X) where 'X' represents the mutant allele. Hence, association has been found between the genetic polymorphism of CYP2C19 and therapeutic response to PPIs. CYP2C19 polymorphism affected eradication of Helicobacter pylori using diferent PPI based eradication therapies as PM patients demonstrated significantly higher eradication rates compared to EMs. CYP2C19 genetic polymorphism also affects the therapeutic outcome of gastroesophageal reflux disease (GERD), reflux oesophagitis and duodenal ulcers. For optimal therapeutic response with PPIs, CYP2C19 pharmacogenetics should be taken into consideration. This shall help in the prescription of optimal doses of PPIs, thus paving the way for personalized medication. |
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Preparedness for AIDS vaccine trials in India |
p. 531 |
JL Excler, S Kochhar, S Kapoor, S Das, J Bahri, Meenakshi Datta Ghosh, NK Ganguly, A Nayyar, M Chataway PMID:18765870India bears a heavy disease burden of HIV/AIDS infected and affected people. A safe, effective and accessible preventive AIDS vaccine, used along with other preventive interventions, is urgently needed to stem the epidemic. This review highlights the extensive preparedness activities undertaken from 2002 by the International AIDS Vaccine Initiative (IAVI), its Indian government and non government partners with the Indian scientific, political, media and community stakeholders and the capacity building process, before the conduct of the first ever AIDS vaccine trials in India in early 2005. Issues addressed included mistrust of clinical research due to past history of some unethical trials, transparency, community involvement, stigma and discrimination, provision for care and treatment of participants, informed consent, gender considerations, approval process, and operational aspects. The strong political support along with preparedness activities led to the successful conduct of AIDS vaccine trials enrolling equitably healthy women and men from all sections of society. This has paved the way for future vaccine trials in the country. |
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ORIGINAL ARTICLES |
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Correlates of overweight & obesity among school going children of Wardha city, Central India  |
p. 539 |
DR Bharati, PR Deshmukh, BS Garg PMID:18765871 |
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Characterisation of depression in patients with schizophrenia |
p. 544 |
A Heald, J Morris, Som D Soni PMID:18765872 |
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Congenital rubella syndrome in infants of women vaccinated during or just before pregnancy with measles-rubella vaccine |
p. 551 |
Mohammad H Namaei, M Ziaee, N Naseh PMID:18765873 |
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Behavioural risk factors for non communicable diseases among adults in Kerala, India |
p. 555 |
TN Sugathan, CR Soman, K Sankaranarayanan PMID:18765874 |
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Anatomy & distribution of coronary arteries in pig in comparison with man |
p. 564 |
D Sahni, GD Kaur, H Jit, I Jit PMID:18765875 |
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Effect of nicotine on lipid profile, peroxidation & antioxidant enzymes in female rats with restricted dietary protein |
p. 571 |
K Chattopadhyay, BD Chattopadhyay PMID:18765876 |
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Pre-operative intravenous fluid therapy with crystalloids or colloids on post-operative nausea & vomiting |
p. 577 |
S Chaudhary, AK Sethi, P Motiani, C Adatia PMID:18765877 |
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Comparison of treatment regimens of kala-azar based on culture & sensitivity of amastigotes to sodium antimony gluconate |
p. 582 |
CP Thakur, S Thakur, S Narayan, A Sinha PMID:18765878 |
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Spread, establishment & prevalence of dengue vector Aedes aegypti (L.) in Konkan region, Maharashtra, India |
p. 589 |
PV Fulmali, A Walimbe, PV Mahadev PMID:18765879 |
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Molecular characterization of shiga like toxin-producing Escherichia coli (STEC) isolates from pigs oedema |
p. 602 |
NN Barman, R Deb, T Ramamurthy, RK Sharma, P Borah, SA Wani, D Kalita PMID:18765880 |
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Age composition of incriminated malaria vector in a rural foothills in West Bengal, India |
p. 607 |
G Chandra PMID:18765881Two 1 yr surveys carried out at a gap of 10 yr revealed nine anopheline species from malaria endemic foothills area of Ayodhya - Baghmindi range of West Bengal, India, with 8.4 per cent populations of Anopheles culicifacies. An. culicifacies was incriminated as vector of Plasmodium falciparum with sporozoite rate of 1.23 per cent. Studies on age composition indicated that proportion parous and daily survival rate of An. culicifacies were assessed to be 0.50 and 0.84 respectively. The survival rate per gonotrophic cycle averaged over the two year was 0.61. Rainy season was found to be the favourable period for transmission. |
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Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells |
p. 610 |
Ya Zhen Shang, Bo Wen Qin, Jian Jun Cheng, H Miao PMID:18765882 |
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CORRESPONDENCES |
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Resurgence of diphtheria in Malegaon & Dhule regions of north Maharashtra |
p. 616 |
MN Dravid, SA Joshi PMID:18765883 |
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Infiltration of Aedes aegypti into peri-urban areas in South Andaman |
p. 618 |
AN Shriram, AP Sugunan, P Vijayachari PMID:18765884 |
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Shigellosis in Puducherry |
p. 621 |
R Dhodapkar, N Srinivas Acharya, BN Harish, SC Parija PMID:18765885 |
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SOME FORTHCOMING SCIENTIFIC EVENTS |
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Some forthcoming scientific events |
p. 623 |
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BOOK RECEIVED |
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Protecting health in Europe from climate change |
p. 624 |
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ANNOUNCEMENTS |
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Announcements |
p. 625 |
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PUBLIC NOTICE |
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Public notice |
p. 626 |
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