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October 2010 Volume 132 | Issue 4
Page Nos. 353-473
Online since Thursday, April 14, 2011
Accessed 12,107 times.
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EDITORIAL |
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Physical illness in persons with schizophrenia - time for action |
p. 353 |
P Munk-Jorgensen PMID:20966510 |
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COMMENTARIES |
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Genetics & hypertension |
p. 356 |
M Khullar PMID:20966511 |
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Zidovudine-induced anaemia in HIV/AIDS |
p. 359 |
Surendra K Sharma PMID:20966512 |
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REVIEW ARTICLE |
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Apolipoprotein E polymorphism in cerebrovascular & coronary heart diseases  |
p. 363 |
S Anoop, A Misra, K Meena, K Luthra PMID:20966513The role of apolipoprotein E (apo E) in lipid metabolism and cholesterol transport is well established. About 14 per cent of the variation in plasma cholesterol levels is attributed to polymorphisms in APO E gene (APO E). APO E consists of three common alleles, designated as ε2, ε3 and ε4 which code for E2, E3 and E4 proteins respectively resulting in three homozygous (E2/E2, E3/E3, E4/E4) and three heterozygous (E3/E2, E4/E2 and E4/E3) phenotypes. Different populations studied worldwide inherit variable frequencies of the APO E alleles and genotypes, with the most frequent allele being ε3.The ε4 allele has been consistently shown to be associated with Alzheimer's disease, coronary heart disease and cerebrovascular disorders. In this review, we have discussed the role of APO E polymorphisms in cerebrovascular and coronary heart diseases. The status of APO E polymorphisms and their disease associations in Asian Indians besides, other populations has also been discussed. Further, studies elucidating the pathophysiology of apo E deficiency conducted in knock-out mice have been reviewed. |
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ORIGINAL ARTICLES |
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Association of aldosterone synthase (CYP11B2 C-344T) gene polymorphism & susceptibility to essential hypertension in a south Indian Tamil population |
p. 379 |
S Rajan, P Ramu, G Umamaheswaran, C Adithan PMID:20966514 |
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High incidence of zidovudine induced anaemia in HIV infected patients in eastern India  |
p. 386 |
D Agarwal, J Chakravarty, L Chaube, M Rai, Nisha Rani Agrawal, S Sundar PMID:20966515 |
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Comparison of HPLC & spectrophotometric methods for estimation of antiretroviral drug content in pharmaceutical products |
p. 390 |
AK Hemanth Kumar, V Sudha, S Swaminathan, G Ramachandran PMID:20966516 |
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Chandipura virus encephalitis outbreak among children in Nagpur division, Maharashtra, 2007 |
p. 395 |
Yogesh K Gurav, Babasaheb V Tandale, Ramesh S Jadi, Rashmi S Gunjikar, Sanjaykumar S Tikute, Aniruddha V Jamgaonkar, Ravindra K Khadse, Suresh V Jalgaonkar, Vidya A Arankalle, Akhilesh C Mishra PMID:20966517 |
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Streptomycin induced protein expression analysis in Mycobacterium tuberculosis by two-dimensional gel electrophoresis & mass spectrometry |
p. 400 |
P Sharma, B Kumar, N Singhal, Vishwa Mohan Katoch, K Venkatesan, Devendra Singh Chauhan, D Bisht PMID:20966518 |
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Pattern & correlates of neurocognitive dysfunction in Asian Indian adults with severe obstructive sleep apnoea |
p. 409 |
H Sharma, Surendra K Sharma, T Kadhiravan, M Mehta, V Sreenivas, V Gulati, S Sinha PMID:20966519 |
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Effect of suicide gene therapy in combination with immunotherapy on antitumour immune response & tumour regression in a xenograft mouse model for head & neck squamous cell carcinoma |
p. 415 |
Aditya V Ambade, Ganesh V Joshi, R Mulherkar PMID:20966520 |
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Prevalence of JAK2 V617F mutation in Indian patients with chronic myeloproliferative disorders |
p. 423 |
S Sazawal, J Bajaj, S Chikkara, S Jain, R Bhargava, M Mahapatra, R Saxena PMID:20966521 |
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Growing up with the families of β-thalassaemia major using an accelerated longitudinal design |
p. 428 |
P Khairkar, S Malhotra, R Marwaha PMID:20966522 |
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Inverse sampling to study disease burden of leprosy |
p. 438 |
A Aggarwal, A Pandey PMID:20966523 |
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Anti-ulcer & antioxidant activities of Hedranthera barteri {(Hook F.) Pichon} with possible involvement of H+, K+ ATPase inhibitory activity |
p. 442 |
Samuel A Onasanwo, N Singh, Samuel B Olaleye, V Mishra, G Palit PMID:20966524 |
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CORRESPONDENCES |
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Introducing pentavalent vaccine in EPI in India : issues involved |
p. 450 |
T Jacob John, J Muliyil PMID:20966525 |
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Pentavalent & other new combination vaccines : solutions in search of problems |
p. 456 |
Y Madhavi, N Raghuram PMID:20966526 |
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Maternal mortality trends in India : Has the policy of promoting institutional delivery paid off? |
p. 458 |
R Kumar, Sharad Kumar Singh, T Dikid PMID:20966527 |
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Antibiotic use for febrile illness in rural paediatric population : questions? |
p. 460 |
D Datta PMID:20966528 |
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Misrepresenting data : deception or dogma? |
p. 463 |
J John, A Bose, V Balraj PMID:20966529 |
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BOOK REVIEWS |
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Book Reviews |
p. 466 |
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SOME FORTHCOMING SCIENTIFIC EVENTS |
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Some Forthcoming Scientific Events |
p. 472 |
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ANNOUNCEMENTS |
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Announcements |
p. 473 |
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