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June 2009 Volume 129 | Issue 6
Page Nos. 625-724
Online since Wednesday, April 20, 2011
Accessed 6,244 times.
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EDITORIAL |
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Acting on climate change is good for health |
p. 625 |
S Kovats PMID:19692739 |
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COMMENTARIES |
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Lactobacilli as probiotics against genital infections |
p. 628 |
S Sethi, G Singh, M Sharma PMID:19692740 |
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Muscoid flies in tsunami hit areas & their management |
p. 631 |
S Prakash, SN Tikar PMID:19692741 |
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Detection of dengue viral infections in Aedes mosquitoes : an essential tool for epidemiological surveillance |
p. 634 |
T John Victor PMID:19692742 |
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REVIEW ARTICLE |
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Cellular & molecular basis of HIV-associated neuropathogenesis |
p. 637 |
D Sharma, J Bhattacharya PMID:19692743Although a plethora of molecules have been implicated in the development of HIV associated dementia (HAD), the identity of the indispensable ones is still elusive. The action of various molecules appears to follow a cascade path with one molecule activating another thereby regulating the expression and modulation of the regulatory machineries. Two pathways have been proposed leading to HIV-induced central nervous system (CNS) injury. First involving neurotoxic effect of viral proteins and second, with immunomodulatory substances secreted by the infected cells playing vital role. The viral transfer from infected cells (for example, cells representing macrophage-microglial lineage) to uninfected cells (such as same cell type or nerve cells) occurring perhaps via virological synapse is also not well documented. While the mechanism underlying transfer of HIV-1 through blood-brain barrier is not clearly understood, macrophage-microglial cell lineages are undisputedly predominant cell types that HIV uses for transmission in CNS. The present review describes existing knowledge of the modus operandi of HIV-induced neuropathogenesis gathered through research evidences. Mechanisms by which regulatory molecules exploit such cell types in promoting neuropathogenesis would provide key insights in intersecting pathway(s) for designing intervention strategies. |
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ORIGINAL ARTICLES |
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Spectrum of Lactobacillus species present in healthy vagina of Indian women |
p. 652 |
Kavita Bansal Garg, I Ganguli, R Das, GP Talwar PMID:19692744 |
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Abundance & distribution of muscoid flies in tsunami-hit coastal villages of southern India during post-disaster management period |
p. 658 |
R Srinivasan, P Jambulingam, K Gunasekaran, P Basker PMID:19692745 |
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Distribution of dengue virus types in Aedes aegypti in dengue endemic districts of Rajasthan, India |
p. 665 |
B Angel, V Joshi PMID:19692746 |
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Effect of gonadotropins on chromosome aneuploidy, chromosome mosaicism & sex ratio in mouse preimplantation embryos |
p. 669 |
A Fauzdar, A Halder, A Kumar PMID:19692747 |
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Screening of codeine, dextromethorphan & dextropropoxyphene for their genotoxicity in Swiss albino mice |
p. 676 |
R Mittal, PA Patil, SS Torgal PMID:19692748 |
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Influence of dietary calcium content on intestinal permeability in rat |
p. 681 |
J Prakasa Rao PMID:19692749 |
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Immunolocalization of CD 34 positive progenitor cells in healthy human gingiva--a pilot study |
p. 685 |
V Lavu, R Padmavathy, Suresh R Rao PMID:19692750 |
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Gender differences in sexual behaviour among people living with HIV in Chennai, India |
p. 690 |
BE Thomas, S Chandra, K.J.A. Selvi, D Suriyanarayanan, S Swaminathan PMID:19692751 |
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Extended spectrum beta-lactamases in Escherichia coli & Klebsiella pneumoniae & associated risk factors |
p. 695 |
A Goyal, KN Prasad, A Prasad, S Gupta, U Ghoshal, A Ayyagari PMID:19692752 |
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Fluoroquinolone resistance among Neisseria gonorrhoeae isolates from Shanghai, China : detection of quinolone resistance-determining region mutations |
p. 701 |
Z Tiejun, Z Xiaoming, Z Jilun, Z Yinghu, R Yanhua, C Yue, G Weiming, Z Tao, J Qingwu PMID:19692753 |
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Simple screening tests for detection of carbapenemases in clinical isolates of nonfermentative Gram-negative bacteria  |
p. 707 |
M.J.C. Noyal, GA Menezes, BN Harish, S Sujatha, SC Parija PMID:19692754 |
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CORRESPONDENCES |
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Comparative evaluation of phenotypic tests for identification of metallo beta-lactamases producing clinical isolates of Pseudomonas aeruginosa |
p. 713 |
Sakshi P Singh, M Shariff, T Barua, SS Thukral PMID:19692755 |
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India's sanitation needs & the millennium development goals |
p. 716 |
G Agoramoorthy PMID:19692756 |
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Haemorrhagic manifestations of dengue fever & their management in a tertiary care hospital in north India |
p. 718 |
Deepinder Kaur Chhina, O Goyal, P Goyal, R Kumar, S Puri, Rajoo Singh Chhina PMID:19692757 |
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BOOK REVIEW |
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Tuberculosis |
p. 721 |
SP Tripathy |
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SOME FORTHCOMING SCIENTIFIC EVENTS |
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Some Forthcoming Scientific Events |
p. 723 |
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ANNOUNCEMENT |
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Announcement |
p. 724 |
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