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EDITORIAL |
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World Tuberculosis Day 2009 : partnership for TB care |
p. 215 |
Hannah Monica Yesudian, Mario C Raviglione PMID:19491410 |
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COMMENTARIES |
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Water contamination : the way forward |
p. 219 |
Philip C Njemanze PMID:19491411 |
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Evaluation of chromatographic & electrophoretic methods for diagnosis of the beta-thalassaemias |
p. 221 |
Roshan B Colah PMID:19491412 |
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REVIEW ARTICLE |
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Potassium channels in health, disease & development of channel modulators |
p. 223 |
S Sandhiya, Steven Aibor Dkhar PMID:19491413Ion channels present in the plasma membrane and intracellular organelles of all cells, play an important role in maintaining cellular integrity, smooth muscle contraction, secretion of hormones and neurotransmitters. Among the ion channels, potassium channels (K(+)) are the most abundant having important role in cardiac repolarization, smooth muscle relaxation and insulin release. These are also involved in the regulation of physiological functions like gastrointestinal peristalsis. These channels are the most diverse of all ion channels and are coded by at least 75 genes. Moreover, these have different subunits which co-assemble to form diverse functional channels. Abnormalities in K(+) channels are associated with diseases like long QT syndrome, Anderson Tawil syndrome, epilepsy, type 2 diabetes mellitus, etc. A number of naturally occurring as well as synthetic compounds have been identified that modulate the opening and closure of K(ATP) Channels. Some of the currently available K(+) channel modulators like sulphonylureas, minoxidil, amiodarone, etc. lack tissue selectivity and have adverse effects. Hence, the success of K(ATP) channel modulators depend on their tissue selectivity. Molecular level studies are needed to understand the type of K(+) channels as this can lead to the development of newer drugs with tissue selectivity for various diseases. |
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ORIGINAL ARTICLES |
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Study of water supply & sanitation practices in India using geographic information systems : some design & other considerations in a village setting |
p. 233 |
S Gopal, R Sarkar, K Banda, J Govindarajan, BB Harijan, MB Jeyakumar, P Mitta, ME Sadanala, T Selwyn, CR Suresh, VA Thomas, P Devadason, R Kumar, D Selvapandian, G Kang, V Balraj PMID:19491414 |
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Comparison of fast protein liquid chromatography (FPLC) with HPLC, electrophoresis & microcolumn chromatography techniques for the diagnosis of β-thalassaemia |
p. 242 |
S Tangvarasittichai, O Tangvarasittichai, N Jermnim PMID:19491415 |
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Doctors' behaviour & skills for tobacco cessation in Kerala |
p. 249 |
KR Thankappan, AS Pradeepkumar, M Nichter PMID:19491416 |
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Haematological & molecular profile of acute myelogenous leukaemia in India |
p. 256 |
S Sazawal, B Kumar, Syed Khizer Hasan, P Dutta, R Kumar, R Chaubey, R Mir, R Saxena PMID:19491417 |
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Prognostic factors in gastric cancer using log-normal censored regression model |
p. 262 |
MA Pourhoseingholi, B Moghimi-Dehkordi, A Safaee, E Hajizadeh, A Solhpour, MR Zali PMID:19491418 |
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Chronology of meiosis & synaptonemal complex abnormalities in normal & abnormal spermatogenesis |
p. 268 |
V Tassistro, R Ghalamoun-Slami, J Saias-Magnan, MR Guichaoua PMID:19491419 |
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Influence of folic acid on plasma homocysteine levels & arterial endothelial function in patients with unstable angina |
p. 279 |
H Guo, J Chi, Y Xing, P Wang PMID:19491420 |
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A case-control study on insulin resistance, metabolic co-variates & prediction score in non-alcoholic fatty liver disease |
p. 285 |
S Bajaj, P Nigam, A Luthra, RM Pandey, D Kondal, SP Bhatt, JS Wasir, A Misra PMID:19491421 |
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Taq1B polymorphism of cholesteryl ester transfer protein (CETP) gene in primary combined hyperlipidaemia |
p. 293 |
T Hassanzadeh, M Firoozrai, Abdolvahhab Ehsani Zonouz, A Zavarehee, M Paoli PMID:19491422 |
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Plasmodium falciparum gametocytaemia with chloroquine chemotherapy in persistent malaria in an endemic area of India |
p. 299 |
PK Kar, VK Dua, NC Gupta, A Gupta, AP Dash PMID:19491423 |
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Association of genital mycoplasmas including Mycoplasma genitalium in HIV infected men with nongonococcal urethritis attending STD & HIV clinics |
p. 305 |
A Manhas, S Sethi, M Sharma, A Wanchu, AJ Kanwar, K Kaur, SD Mehta PMID:19491424 |
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A study on chikungunya outbreak during 2007 in Kerala, south India |
p. 311 |
M Kannan, R Rajendran, IP Sunish, R Balasubramaniam, N Arunachalam, R Paramsivan, SC Tewari, P Philip Samuel, BK Tyagi PMID:19491425 |
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PCR-based detection of enterotoxigenic isolates of Bacillus cereus from tropical seafood |
p. 316 |
S Das, PK Surendran, Nirmala K Thampuran PMID:19491426 |
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Call for more research on injury from the developing world : results of a bibliometric analysis  |
p. 321 |
NN Borse, AA Hyder PMID:19491427 |
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CORRESPONDENCES |
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Sample survey for indigenous cases of kala-azar in Assam by rk39 dipstick test |
p. 327 |
AM Khan, K Pandey, V Kumar, P Dutta, P Das, J Mahanta PMID:19491428 |
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Sero-entomological investigations on Japanese encephalitis outbreak in Gorakhpur division, Uttar Pradesh, India |
p. 329 |
P Philip Samuel, K Ayanar, M Kannan, V Thenmozhi, R Paramasivan, A Balasubramanian, BK Tyagi PMID:19491429 |
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Penicillium marneffei infection in HIV infected patients in Nagaland & immune reconstitution after treatment |
p. 333 |
L Saikia, R Nath, P Biswanath, D Hazarika, J Mahanta PMID:19491430 |
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Molecular characterization of chikungunya virus from Andhra Pradesh, India |
p. 335 |
PK Kar, BN Nagpal, VK Dua, SK Ghosh, K Raghavendra, RM Bhatt, A Anvikar, A Das PMID:19491431 |
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Authors' response |
p. 337 |
C.V.M. Naresh Kumar, D.V.R. Sai Gopal |
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Holistic approach for global mental health |
p. 338 |
S Jaju PMID:19491433 |
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Vaccine introduction where incidence of Hib meningitis is 0.007% : decision-making based on health economic or ideology? |
p. 339 |
N Gupta, Jacob M Puliyel PMID:19491434 |
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BOOK REVIEW |
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Behaviour therapy: Techniques, research and applications |
p. 341 |
Meena Hariharan |
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SOME FORTHCOMING SCIENTIFIC EVENTS |
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Some Forthcoming Scientific Events |
p. 343 |
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ANNOUNCEMENT |
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Announcement |
p. 344 |
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