Indian Journal of Medical Research

REVIEW ARTICLE
Year
: 2021  |  Volume : 153  |  Issue : 1  |  Page : 17--25

An overview of preclinical animal models for SARS-CoV-2 pathogenicity


Itti Munshi1, Aditya Khandvilkar1, Shrinivas M Chavan1, Geetanjali Sachdeva1, Smita D Mahale2, Uddhav K Chaudhari1 
1 Department of Primate Biology, ICMR-National Institute for Research in Reproductive Health, Mumbai, Maharashtra, India
2 Department of Structural Biology, ICMR-National Institute for Research in Reproductive Health, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Uddhav K Chaudhari
Division of Primate Biology, ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, Maharashtra
India

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused millions of fatalities globally since its origin in November 2019. The SARS-CoV-2 shares 79 and 50 per cent genome similarity with its predecessors, severe SARS-CoV and Middle East respiratory syndrome (MERS) coronavirus, all belonging to the same genus, Betacoronavirus. This relatively new virus has stymied the effective control of COVID-19 pandemic and caused huge social and economic impact worldwide. The FDA-approved drugs were re-purposed to reduce the number of fatalities caused by SARS-CoV-2. However, controversy surrounds about the efficacy of these re-purposed antiviral drugs against SARS-CoV-2.This necessitates the identification of new drug targets for SARS-CoV-2. Hence, the development of pre-clinical animal model is warranted. Such animal models may help us gain better understanding of the pathophysiology of SARS-CoV-2 infection and will be effective tools for the evaluation and licensure of therapeutic strategies against SARS-CoV-2. This review provides a summary of the attempts made till to develop a suitable animal model to understand pathophysiology and effectiveness of therapeutic agents against SARS-CoV-2.


How to cite this article:
Munshi I, Khandvilkar A, Chavan SM, Sachdeva G, Mahale SD, Chaudhari UK. An overview of preclinical animal models for SARS-CoV-2 pathogenicity.Indian J Med Res 2021;153:17-25


How to cite this URL:
Munshi I, Khandvilkar A, Chavan SM, Sachdeva G, Mahale SD, Chaudhari UK. An overview of preclinical animal models for SARS-CoV-2 pathogenicity. Indian J Med Res [serial online] 2021 [cited 2021 Apr 22 ];153:17-25
Available from: https://www.ijmr.org.in/article.asp?issn=0971-5916;year=2021;volume=153;issue=1;spage=17;epage=25;aulast=Munshi;type=0