Indian Journal of Medical Research

CLINICAL IMAGE
Year
: 2020  |  Volume : 152  |  Issue : 7  |  Page : 57-

Cyclopia syndrome with normal karyotype


Sayan Banerjee, Debasree Guha 
 Department of Pediatric Medicine, R.G. Kar Medical College and Hospital, Kolkata 700 004, West Bengal, India

Correspondence Address:
Debasree Guha
Department of Pediatric Medicine, R.G. Kar Medical College and Hospital, Kolkata 700 004, West Bengal
India




How to cite this article:
Banerjee S, Guha D. Cyclopia syndrome with normal karyotype.Indian J Med Res 2020;152:57-57


How to cite this URL:
Banerjee S, Guha D. Cyclopia syndrome with normal karyotype. Indian J Med Res [serial online] 2020 [cited 2021 Sep 27 ];152:57-57
Available from: https://www.ijmr.org.in/text.asp?2020/152/7/57/316737


Full Text

A one-eyed late preterm female neonate† was born of a non-consanguineous marriage in the month of December 2018, at the department of Gynecology and Obstetrics, R.G. Kar Medical College and Hospital, Kolkata, India. A diagnosis of a case of cyclopia was made on the basis of a partially divided eye in a single orbit, absent nose, proboscis above the eye [Figure 1]. Other noticeable anomalies included Polydactyly of hand. This condition was named after the single eyed giant 'Cyclops' in Greek mythology. The aetiology remains largely unknown. Some cases may have chromosomal abnormalities (namely trisomy 13), but karyotyping in this case was normal [Figure 2]. It is the severe most expression of holoprosencephaly syndrome, with severe facial dysmorphism. Supportive management was given, but the neonate died after one hour of birth. Antenatal ultrasonography should take a lead in early detection of such rare cases incompatible with life, and termination of the pregnancy should follow.{Figure 1}{Figure 2}

Conflicts of Interest: None.