Indian Journal of Medical Research

CLINICAL IMAGE
Year
: 2020  |  Volume : 152  |  Issue : 7  |  Page : 40--41

Sirolimus for multifocal infantile haemangiomas with hepatic & adrenal involvement


Jhuma Sankar1, Prasenjit Das2,  
1 Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110 029, India
2 Department of Pathology, All India Institute of Medical Sciences, New Delhi 110 029, India

Correspondence Address:
Jhuma Sankar
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110 029
India




How to cite this article:
Sankar J, Das P. Sirolimus for multifocal infantile haemangiomas with hepatic & adrenal involvement.Indian J Med Res 2020;152:40-41


How to cite this URL:
Sankar J, Das P. Sirolimus for multifocal infantile haemangiomas with hepatic & adrenal involvement. Indian J Med Res [serial online] 2020 [cited 2021 Sep 27 ];152:40-41
Available from: https://www.ijmr.org.in/text.asp?2020/152/7/40/316724


Full Text

Multifocal haemangiomas are a rare subtype of infantile haemangiomas (IHs) with multiple complications.

A 40 day old male infant† with multifocal IH presented to the Emergency department at the All India Institute of Medical Sciences, New Delhi, India, in January 2019, with eye involvement, liver failure and high-output cardiac failure [Figure 1]A. The child was initially managed with propranolol to which the lesions were refractory. Angiogenesis inhibitor sirolimus was tried with good clinical response. The lesions regressed in size [Figure 1]B and liver functions improved after two weeks of therapy. Unfortunately, the child succumbed to a nosocomial infection at four weeks of intensive care unit stay. Post-mortem examination revealed multifocal haemangiomas in the liver [Figure 2]A and adrenal gland [Figure 2]B. The histopathology confirmed IHs [Figure 3]. This case highlights the challenges faced by the treating team in managing multifocal haemangiomas with hepatic involvement. Sirolimus appears to be a promising therapy in these cases.{Figure 1}{Figure 2}{Figure 3}

Acknowledgment: Authors acknowledge the contributions of Drs Viswanath, Sagar Tugal and Rakesh Lodha from the department of Pediatrics and Dr Hena Khandakar from the department of Pathology in the case management and for providing images.

Conflicts of Interest: None