Indian Journal of Medical Research

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 150  |  Issue : 5  |  Page : 468--476

Frequent plateletpheresis donations & its effect on haematological parameters: An observational study


Sweta Nayak1, Poonam Coshic1, RM Pandey2, Kabita Chatterjee1 
1 Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, India
2 Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Dr Poonam Coshic
Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi 110 029
India

Background & objectives: The well-being of donors undergoing frequent plateletpheresis has been a matter of concern. The aim of this study was to analyze the effect of frequent plateletpheresis on the haematological parameters (HP) of repeat donors. Methods: The study was conducted during February 2016 to March 2017 on all the repeat plateletpheresis donors undergoing the 2nd plateletpheresis within a month of the first in a tertiary care centre. Donors repeating plateletpheresis 3rd and 4th times were also studied. The values of the HP observed on follow up after plateletpheresis done on three different separators were compared. Results: HPs of the 98 donors were similar at follow up except mean platelet volume (P <0.05). Of the 98 donors, 35 were followed up within a week and 63 were followed up within 8-30 days. No significant alteration was found in the HPs except a significant difference in the variation of platelet counts of the two groups (P=0.025). In 34 donors who presented 3rd time for plateletpheresis (mean gap between 1st and 3rd plateletpheresis=31 days), no significant differences in the HPs were found except the platelet distribution width (P <0.05). Minimal difference in the HP was found in the baseline and the follow up of 3rd plateletpheresis i.e., at 4th plateletpheresis donation. Plateletpheresis through all the three cell separators used had similar effects on the follow up HPs. Interpretation & conclusions: Repeated plateletpheresis can be done without any detrimental effects on the cell counts of the plateletpheresis donors. The three cell separators yielded similar post-donation follow up haematological parameters.


How to cite this article:
Nayak S, Coshic P, Pandey R M, Chatterjee K. Frequent plateletpheresis donations & its effect on haematological parameters: An observational study.Indian J Med Res 2019;150:468-476


How to cite this URL:
Nayak S, Coshic P, Pandey R M, Chatterjee K. Frequent plateletpheresis donations & its effect on haematological parameters: An observational study. Indian J Med Res [serial online] 2019 [cited 2020 Nov 30 ];150:468-476
Available from: https://www.ijmr.org.in/article.asp?issn=0971-5916;year=2019;volume=150;issue=5;spage=468;epage=476;aulast=Nayak;type=0