Year : 2019 | Volume
: 149 | Issue : 6 | Page : 755--762
Evaluation of new non-invasive & conventional invasive methods of haemoglobin estimation in blood donors
Diptiranjan Rout, Suchet Sachdev, Neelam Marwaha
Department of Transfusion Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India
Background & objectives: The non-invasive method of haemoglobin (Hb) estimation has unique advantages of exemption of finger prick and associated pain, over invasive methods. This study was done to compare invasive and non-invasive methods of Hb estimation in blood donors keeping haematology analyzer (HA) as a reference method.
Methods: The blood donors selected or deferred on the basis of CuSO4method (Hb ≥12.5 g/dl), were included in the study. Hb values of the donors were estimated by HemoCue and then by OrSense methods. An immediate post-donation venous sample was drawn for analysis on HA.
Results: The mean Hb value was 13.98±1.27 g/dl on HA, 14.87±1.03 g/dl on OrSense and 15.03±1.31 g/dl on HemoCue. CuSO4, HemoCue and OrSense demonstrated sensitivities of 18.7, 18.7 and 13.1 per cent, positive predictive values (PPV) of 64.5, 83.3 and 60.9 per cent and specificities of 98.9, 99.6 and 99.1 per cent, respectively. The intra-class correlation coefficient for OrSense was 0.726 while that for HemoCue was 0.851. Bland-Altman plots demonstrated 2SD difference of >2.0 g/dl in Hb estimations between HA and HemoCue/OrSense.
Interpretation & conclusions: The non-invasive modality may provide the near-ideal pre-donation Hb screening platform if an improvement can be done in the sensitivity and PPV of the non-invasive method keeping in view its unique advantages.
Dr Suchet Sachdev
Department of Transfusion Medicine, Postgraduate Institute of Medical Education & Research, Sector 12, Chandigarh 160 012
|How to cite this article:|
Rout D, Sachdev S, Marwaha N. Evaluation of new non-invasive & conventional invasive methods of haemoglobin estimation in blood donors.Indian J Med Res 2019;149:755-762
|How to cite this URL:|
Rout D, Sachdev S, Marwaha N. Evaluation of new non-invasive & conventional invasive methods of haemoglobin estimation in blood donors. Indian J Med Res [serial online] 2019 [cited 2021 Jan 20 ];149:755-762
Available from: https://www.ijmr.org.in/article.asp?issn=0971-5916;year=2019;volume=149;issue=6;spage=755;epage=762;aulast=Rout;type=0