Indian Journal of Medical Research

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 146  |  Issue : 3  |  Page : 369--374

Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury


Oguz Kayiran1, Suat Sedat Cuzdan2, Afsin Uysal3, Ugur Kocer4 
1 Department Plastic & Reconstructive Surgery, Izmir University, Izmir, Turkey
2 Plastic Surgery Clinic, Sanmed Private Hospital, Sanliurfa, Turkey
3 Plastic & Reconstructive Surgery Clinic, TOBB ETU Hospital, Ankara, Turkey
4 Plastic & Reconstructive Surgery Clinic, Ankara Training & Research Hospital, Ankara, Turkey

Correspondence Address:
Dr Oguz Kayiran
Baltalimani Training and Research Hospital, Plastic & Reconstructive Surgery Clinic, Rumelihsari Cd, No:62, Baltalimani, Sariyer
Turkey

Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase). Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P<0.05) in the levels of these markers between ischaemic and medication groups. Ethyl pyruvate improved all the parameters significantly. Interpretation & conclusion: Ethyl pyruvate showed strong scavenger activity against reactive oxygen species. It could be a potential candidate to improve the flap viability in reconstructive microsurgery, especially in free tissue transfers. However, more studies are warranted in experimental models to confirm these findings.


How to cite this article:
Kayiran O, Cuzdan SS, Uysal A, Kocer U. Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury.Indian J Med Res 2017;146:369-374


How to cite this URL:
Kayiran O, Cuzdan SS, Uysal A, Kocer U. Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury. Indian J Med Res [serial online] 2017 [cited 2020 Nov 23 ];146:369-374
Available from: https://www.ijmr.org.in/article.asp?issn=0971-5916;year=2017;volume=146;issue=3;spage=369;epage=374;aulast=Kayiran;type=0