Indian Journal of Medical Research

REVIEW ARTICLE
Year
: 2017  |  Volume : 146  |  Issue : 3  |  Page : 316--327

Interplay of cytokines in preterm birth


Monika Pandey, Mradula Chauhan, Shally Awasthi 
 Department of Pediatrics, Translational Medicine Unit, King George's Medical University, Lucknow, India

Correspondence Address:
Dr Shally Awasthi
Department of Pediatrics, Translational Medicine Unit, King George's Medical University, Lucknow 226 003, Uttar Pradesh
India

Preterm infants (i.e., born before <37 wk of gestation) are at increased risk of morbidity and mortality and long-term disabilities. Global prevalence of preterm birth (PTB) varies from 5 to 18 per cent. There are multiple aetiological causes and factors associated with PTB. Intrapartum infections are conventionally associated with PTB. However, maternal genotype modulates response to these infections. This review highlights the association of cytokine gene polymorphisms and their levels with PTB. Varying PTB rates across the different ethnic groups may be as a result of genetically mediated varying cytokines response to infections. Studies on genetic variations in tumour necrosis factor-alpha, interleukin-1 alpha (IL-1α), IL-1β, IL-6, IL-10 and toll-like receptor-4 genes and their association with PTB, have been reviewed. No single polymorphism of the studied genes was found to be associated with PTB. However, increased maternal levels of IL-1β and IL-6 and low levels of IL-10 have been found to be associated with PTB.


How to cite this article:
Pandey M, Chauhan M, Awasthi S. Interplay of cytokines in preterm birth.Indian J Med Res 2017;146:316-327


How to cite this URL:
Pandey M, Chauhan M, Awasthi S. Interplay of cytokines in preterm birth. Indian J Med Res [serial online] 2017 [cited 2020 Dec 3 ];146:316-327
Available from: https://www.ijmr.org.in/article.asp?issn=0971-5916;year=2017;volume=146;issue=3;spage=316;epage=327;aulast=Pandey;type=0