Indian Journal of Medical Research

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 145  |  Issue : 6  |  Page : 758--766

Association of rheumatic fever & rheumatic heart disease with plausible early & late-stage disease markers


Subendu Sarkar1, Mukul Rastogi1, Priyanka Chaudhary2, Rajesh Kumar2, Priya Arora1, Vivek Sagar2, Inderpal Singh Sahni2, Sunil Shethi3, Khemraj Thakur1, Sourav Ailawadhi1, Devinder Toor2, Anuradha Chakraborti1 
1 Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
2 School of Public Health, Postgraduate Institute of Medical Education & Research, Chandigarh, India
3 Department of Medical Microbiology, Postgraduate Institute of Medical Education & Research, Chandigarh, India

Correspondence Address:
Anuradha Chakraborti
Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh 160 012
India

Background & objectives: Rheumatic fever (RF) and rheumatic heart disease (RHD) are the autoimmune sequelae caused by Group A Streptococcus. RHD still remains a major concern in the developing countries due to its poor diagnosis, lack of vaccines and social awareness among population. This study was aimed to identify the plausible early- and late-stage disease markers associated with RF/RHD. Methods: A total of 84 patients with confirmed pharyngitis (n=18), RF (n=23) and RHD (n=43) were included in the comparative analysis of different factors involved in host-pathogen interaction during RF/RHD pathogenesis. Results: This study revealed high titre of serum antistreptolysin O (ASO) antibody in pharyngitis compared to RF and RHD patients, whereas procollagen type 1 C-peptide (PICP) level was elevated in RHD which showed an inverse correlation with serum ASO titre. The significant elevation of serum anti-peptide associated with RF (PARF) antibody in RF patients was correlated as a probable stage-specific determinant. In addition, pro-inflammatory cytokine profile revealed high levels of interleukin-12 (IL-12)/IL-23p40, IL-17A in RF, whereas IL-6 concentration was higher in RHD compared to healthy controls. Interpretation & conclusions: The overall assessment of the factors/ disease markers involved in host-pathogen interaction in RF/RHD may be suggestive of plausible disease marker in different groups of patients. Further studies with larger sample need to be done to better understand RF/RHD pathogenesis.


How to cite this article:
Sarkar S, Rastogi M, Chaudhary P, Kumar R, Arora P, Sagar V, Sahni IS, Shethi S, Thakur K, Ailawadhi S, Toor D, Chakraborti A. Association of rheumatic fever & rheumatic heart disease with plausible early & late-stage disease markers.Indian J Med Res 2017;145:758-766


How to cite this URL:
Sarkar S, Rastogi M, Chaudhary P, Kumar R, Arora P, Sagar V, Sahni IS, Shethi S, Thakur K, Ailawadhi S, Toor D, Chakraborti A. Association of rheumatic fever & rheumatic heart disease with plausible early & late-stage disease markers. Indian J Med Res [serial online] 2017 [cited 2021 Apr 18 ];145:758-766
Available from: https://www.ijmr.org.in/article.asp?issn=0971-5916;year=2017;volume=145;issue=6;spage=758;epage=766;aulast=Sarkar;type=0