Indian Journal of Medical Research

REVIEW ARTICLE
Year
: 2015  |  Volume : 142  |  Issue : 4  |  Page : 369--382

Alzheimer«SQ»s disease: Unique markers for diagnosis & new treatment modalities


Neelum T Aggarwal, Raj C Shah, David A Bennett 
 Department of Neurology, Rush Alzheimer's Disease Center & Family Medicine at Rush University Medical Center, Chicago, USA

Correspondence Address:
Neelum T Aggarwal
Rush University Medical Center, 600 South Paulina, 1038 AAC, Chicago, I1 60612
USA

Alzheimer«SQ»s disease (AD) is a progressive and irreversible neurodegenerative disease. In humans, AD becomes symptomatic only after brain changes occur over years or decades. Three contiguous phases of AD have been proposed: (i) the AD pathophysiologic process, (ii) mild cognitive impairment due to AD, and (iii) AD dementia. Intensive research continues around the world on unique diagnostic markers and interventions associated with each phase of AD. In this review, we summarize the available evidence and new therapeutic approaches that target both amyloid and tau pathology in AD and discuss the biomarkers and pharmaceutical interventions available and in development for each AD phase.


How to cite this article:
Aggarwal NT, Shah RC, Bennett DA. Alzheimer's disease: Unique markers for diagnosis & new treatment modalities.Indian J Med Res 2015;142:369-382


How to cite this URL:
Aggarwal NT, Shah RC, Bennett DA. Alzheimer's disease: Unique markers for diagnosis & new treatment modalities. Indian J Med Res [serial online] 2015 [cited 2020 Nov 24 ];142:369-382
Available from: https://www.ijmr.org.in/article.asp?issn=0971-5916;year=2015;volume=142;issue=4;spage=369;epage=382;aulast=Aggarwal;type=0