Indian Journal of Medical Research

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 139  |  Issue : 6  |  Page : 940--944

Circulation of hepatitis A genotype IIIA virus in paediatric patients in central India


PV Barde, MK Shukla, Ruchi Pathak, BK Kori, PK Bharti 
 Regional Medical Research Centre for Tribals (ICMR), Jabalpur, India

Correspondence Address:
P V Barde
Scientist C, Regional Medical Research Centre for Tribals, (ICMR), Nagpur Road, Garha ,Jabalpur 482 003
India

Hepatitis A virus (HAV) infection, a major cause of childhood hepatitis is transmitted by orofaecal route. Children mostly suffer with subclinical infection but may have serious clinical implications leading to hospitalization and mortality. IgM ELISA and nRT PCR were conducted on the blood samples collected from HAV suspected paediatric cases referred to the viral diagnostic laboratory in the Regional Medical Research Centre for Tribals at Jabalpur, Central India. The nRT PCR products were sequenced and phylogenetic analysis was done. o0 f the 195 samples tested, 41 (21%) were positive for HAV antibodies, among which 38 (92%) belonged to paediatric age group and 32 per cent of these were hospitalized. nRT PCR and sequencing confirmed the presence of HAV. Phylogenic analysis revealed circulation of genotype III A in central India. Regular serological and molecular monitoring would aid in understanding epidemiology of HAV and plan intervention strategies.


How to cite this article:
Barde P V, Shukla M K, Pathak R, Kori B K, Bharti P K. Circulation of hepatitis A genotype IIIA virus in paediatric patients in central India.Indian J Med Res 2014;139:940-944


How to cite this URL:
Barde P V, Shukla M K, Pathak R, Kori B K, Bharti P K. Circulation of hepatitis A genotype IIIA virus in paediatric patients in central India. Indian J Med Res [serial online] 2014 [cited 2021 Mar 5 ];139:940-944
Available from: https://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=139;issue=6;spage=940;epage=944;aulast=Barde;type=0