Indian Journal of Medical Research

CORRESPONDENCE
Year
: 2013  |  Volume : 138  |  Issue : 4  |  Page : 562--563

Higher homocysteine levels in young Indian adults: Impact of vitamin B12 & folate deficiencies


Tuba Muftuoglu1, Omer Ozcan1, Alpaslan Cosar2, Mustafa Gultepe1,  
1 GATA Haydarpasa Training Hospital, Department of Clinical Biochemistry, Istanbul, Turkey
2 Van Military Hospital, Chemistry Laboratory, Van, Turkey

Correspondence Address:
Tuba Muftuoglu
GATA Haydarpasa Training Hospital, Department of Clinical Biochemistry, Istanbul
Turkey




How to cite this article:
Muftuoglu T, Ozcan O, Cosar A, Gultepe M. Higher homocysteine levels in young Indian adults: Impact of vitamin B12 & folate deficiencies.Indian J Med Res 2013;138:562-563


How to cite this URL:
Muftuoglu T, Ozcan O, Cosar A, Gultepe M. Higher homocysteine levels in young Indian adults: Impact of vitamin B12 & folate deficiencies. Indian J Med Res [serial online] 2013 [cited 2021 Jan 18 ];138:562-563
Available from: https://www.ijmr.org.in/text.asp?2013/138/4/562/121557


Full Text

Sir,

An article by Gupta and colleagues [1] on the role of homocysteine and MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians, published recently provides information about the risk factors of coronary artery disease; high levels of homocysteine, total cholesterol, LDL cholesterol and low levels of HDL cholesterol and smoking as an independent predictors in young Indians. There are certain issues which need to be clarified:

First, the blood homocyteine levels were used as one of the main parameters measured in the cases and controls. As the authors also emphasized, mean blood homocysteine levels were found higher than the normal range in both cases and controls. They explained this state, the possible result of dietary deficiency of vitamin B6, B12 and folic acid as seen in Indian population [2],[3] . Thus the reason for higher homocysteine levels observed in both the groups due to either MTHFR mutations or dietary vitamin deficiencies could not be assessed clearly. They did not measure blood folate and vitamin B12 levels to evaluate these deficiencies. The effect of vitamin deficiencies on the results of this study might be as a confounding factor. It could be suggested that measuring blood levels of vitamin B12 and folate might lead to a better evaluation of study groups according to their deficiency states. Assessment of groups separately would enable to interpret the effects of vitamin B12 and folic acid administration more precisely.

Second, according to [Table 3] which shows the mean levels of cholesterol, LDL-C, HDL-C, triglycerides levels, the mean total cholesterol level (154 mg/dl) is lower than LDL cholesterol level (157 mg/dl) in the control group. Since total cholesterol level could not be lower than LDL-C concentrations, there appears to be a possible typographic error in the value of mean LDL-C levels of controls group.

References

1Gupta SK, Kotwal J, Kotwal A, Dhall A, Garg S. Role of homocysteine & MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians. Indian J Med Res 2012; 135 : 506-12.
2Nath I, Reddy KS, Dinshaw KA, Bhisey AN, Krishnaswami K, Bhan MK, et al. Country profile: India. Lancet 1998; 351 : 1265-75.
3Refsum H, Yajnik CS, Gadkari M, Schneede J, Vollset stein E, Orning L, et al. Homocyteine and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indian. Am J Clin Nutr 2001; 74 : 233-41.