Indian Journal of Medical Research

REVIEW ARTICLE
Year
: 2009  |  Volume : 130  |  Issue : 3  |  Page : 296--310

Anti-human papillomavirus therapeutics : facts & future


Alok C Bharti1, S Shukla1, S Mahata1, S Hedau1, Bhudev C Das2 
1 Division of Molecular Oncology, Institute of Cytology & Preventive Oncology (ICMR), Noida, India
2 Dr B.R. Ambedkar Center for Biomedical Research, University of Delhi (North Campus), Delhi 110 007, India

Correspondence Address:
Bhudev C Das
Dr B.R. Ambedkar Center for Biomedical Research, University of Delhi (North Campus), Delhi 110 007, India

Even after 25 years of establishing Human Papillomavirus (HPV) as the causative agent for cervical cancer, effective treatment of HPV infection still unavailable. Comprehensive efforts especially for targeting HPV infection have been made only in recent years. Conventional physical ablation of HPV-induced lesions such as cryo-therapy, photo-therapy, LEEP, laser cone-biopsy and localized radiotherapy are shown to be effective to some extent in treating localized lesions where the removal of diseased tissue is associated with removal of transforming keratinocytes harboring HPV. Apart from currently available prophylactic vaccines which prevent the viral entry and should be given prior to viral exposure, several attempts are being made to develop therapeutic vaccines that could treat prevailing HPV infection. In addition, immunomodulators like interferons and imiquimod that have been shown to elicit cytokine milieu to enhance host immune response against HPV infection. Also, antiviral approaches such as RNA interference (RNAi) nucleotide analogs, antioxidants and herbal derivatives have shown effective therapeutic potential against HPV infection. These leads are being tested in pre-clinical and clinical studies. Present article provides a brief overview of conventional therapies for HPV-associated diseases. Potential of non-ablative anti-HPV treatment modalities that could prove useful for either elimination of HPV in early stages of infection when the virus is not integrated into the host cell genome or suppression of the expression of viral oncogenes that dys-regulate the host cell cycle following transformation is discussed.


How to cite this article:
Bharti AC, Shukla S, Mahata S, Hedau S, Das BC. Anti-human papillomavirus therapeutics : facts & future.Indian J Med Res 2009;130:296-310


How to cite this URL:
Bharti AC, Shukla S, Mahata S, Hedau S, Das BC. Anti-human papillomavirus therapeutics : facts & future. Indian J Med Res [serial online] 2009 [cited 2021 Jan 25 ];130:296-310
Available from: https://www.ijmr.org.in/article.asp?issn=0971-5916;year=2009;volume=130;issue=3;spage=296;epage=310;aulast=Bharti;type=0