Indian Journal of Medical Research

REVIEW ARTICLE
Year
: 2006  |  Volume : 124  |  Issue : 6  |  Page : 613--618

Autologous transplantation in the central nervous system


P Taupin 
 National Neuroscience Institute, National University of Singapore & Nanyang Technological University, Singapore

Correspondence Address:
P Taupin
National Neuroscience Institute, National University of Singapore & Nanyang Technological University, Singapore

Cell transplantation has been proposed to replace lost neurons in the diseased brain, and after injuries to the central nervous system (CNS). Strategies for cellular therapy in the CNS consist primarily in heterologous transplantations. Despite the CNS being an immunologically privileged site, immune rejection of intracerebral transplants remains a concern. In addition, the use of immunosuppressive drugs, like cyclosporine, is a major constraint associated with heterologous transplantations. Autologous transplantation is therefore viewed as the model of choice for cellular therapy. With the recent progress in somatic cell nuclear transfer (SCNT) research, and the confirmation that neurogenesis occurs in the adult brain and neural stem cells (NSCs) reside in the adult CNS, new opportunities for autologous transplantations are being considered for the CNS, and are promising.


How to cite this article:
Taupin P. Autologous transplantation in the central nervous system.Indian J Med Res 2006;124:613-618


How to cite this URL:
Taupin P. Autologous transplantation in the central nervous system. Indian J Med Res [serial online] 2006 [cited 2021 Jan 28 ];124:613-618
Available from: https://www.ijmr.org.in/article.asp?issn=0971-5916;year=2006;volume=124;issue=6;spage=613;epage=618;aulast=Taupin;type=0