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REVIEW ARTICLE
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Use of convalescent plasma for COVID-19 in India: A review & practical guidelines


1 Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India
2 Department of Anaesthesia & Intensive Care, Postgraduate Institute of Medical Education & Research, Chandigarh, India
3 Department of Transfusion Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India
4 Department of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
5 Department of Virology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
6 Clinical Trial & Health System Research Unit, Division of Epidemiology & Communicable Diseases, Indian Council of Medical Research, New Delhi, India

Correspondence Address:
Pankaj Malhotra,
Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh 160 012
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijmr.IJMR_3092_20

PMID: 33533733

Convalescent plasma (CP) therapy is one of the promising therapies being tried for COVID-19 patients. This passive immunity mode involves separating preformed antibodies against SARS-CoV-2 from a recently recovered COVID-19 patient and infusing it into a patient with active disease or an exposed individual for prophylaxis. Its advantages include ease of production, rapid deployment, specificity against the target infectious agent, and scalability. In the current pandemic, it has been used on a large scale across the globe and also in India. However, unequivocal proof of efficacy and effectiveness in COVID-19 is still not available. Various CP therapy parameters such as donor selection, antibody quantification, timing of use, and dosing need to be considered before its use. The current review attempts to summarize the available evidence and provide recommendations for setting up CP protocols in clinical and research settings.


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