Demographic & clinical profile of patients with COVID-19 at a tertiary care hospital in north India Soni SL, Kajal K, Yaddanapudi LN, Malhotra P, Puri GD, Bhalla A, Singh MP, Sehgal IS, Koushal V, Varma N, Biswal M, Lakshmi P, Sharma S, Suri V, Deepy Z, Ram S, Yadav J, Pandey N, Sharma P, Malik N, Goyal K, Mehra A, Sahoo S, Mohindra R, Francis J, Bhargava M, Singla K, Babu P, Verma A, Khaire NS, Guru RR,

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Demographic & clinical profile of patients with COVID-19 at a tertiary care hospital in north India Shiv Lal Soni¹, Kamal Kajal¹, L. N. Yaddanapudi¹, Pankaj Malhotra², Goverdhan Dutt Puri¹, Ashish Bhalla², Mini P. Singh³, Inderpaul Singh Sehgal⁴, Vipin Koushal⁵, Neelam Varma⁶, Manisha Biswal⁷, P.V.M. Lakshmi⁸, Sadhna Sharma⁹, Vikas Suri², Z. Deepy⁹, Sant Ram⁹, Jaivinder Yadav¹⁰, Navin Pandey⁵, Prashant Sharma¹¹, Nabhajit Malik¹¹, Kapil Goyal³, Aseem Mehra¹², Swapnajeet Sahoo¹², Ritin Mohindra², Jijo Francis¹, Mudit Bhargava², Karan Singla¹, Preena Babu¹, Amiy Verma¹, Niranjan Shiwaji Khaire², R. R. Guru⁵ ¹ Department of Anaesthesia & Intensive Care, Postgraduate Institute of Medical Education & Research, Chandigarh, India ² Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India ³ Department of Virology, Postgraduate Institute of Medical Education & Research, Chandigarh, India ⁴ Department of Pulmonary Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India ⁵ Department of Hospital Administration, Postgraduate Institute of Medical Education & Research, Chandigarh, India ⁶ Department of Pathology, Postgraduate Institute of Medical Education & Research, Chandigarh, India ⁷ Department of Medical Microbiology, Postgraduate Institute of Medical Education & Research, Chandigarh, India ⁸ Department of Community Medicine & School of Public Health, Postgraduate Institute of Medical Education & Research, Chandigarh, India ⁹ Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh, India ¹⁰ Department of Pediatrics, Postgraduate Institute of Medical Education & Research, Chandigar, India ¹¹ Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India ¹² Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India Correspondence Address: Vikas Suri, Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Sector 12, Chandigarh 160 012 India Source of Support: None, Conflict of Interest: None DOI: 10.4103/ijmr.IJMR_2311_20 PMID: 33208558

*Background & objectives:* The COVID-19 pandemic emerged as a major public health emergency affecting the healthcare services all over the world. It is essential to analyze the epidemiological and clinical characteristics of patients with COVID-19 in different parts of our country. This study highlights clinical experience in managing patients with COVID-19 at a tertiary care centre in northern India. *Methods:* Clinical characteristics and outcomes of consecutive adults patients admitted to a tertiary care hospital at Chandigarh, India, from April 1 to May 25, 2020 were studied. The diagnosis of SARS-CoV-2 infection was confirmed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) on throat and/or nasopharyngeal swabs. All patients were managed according to the institute's consensus protocol and in accordance with Indian Council of Medical Research guidelines. *Results:* During the study period, 114 patients with SARS-CoV-2 infection were admitted. The history of contact with COVID-19-affected individuals was available in 75 (65.8%) patients. The median age of the patients was 33.5 yr (13-79 yr), and there were 66 (58%) males. Of the total enrolled patients, 48 (42%) were symptomatic. The common presenting complaints were fever (37, 77%), cough (26, 54%) and shortness of breath (10, 20.8%). Nineteen (17%) patients had hypoxia (SpO2<94%) at presentation and 36 (31%) had tachypnoea (RR >24). Thirty four (29.8%) patients had an accompanying comorbid illness. Age more than 60 yr and presence of diabetes and hypertension were significantly associated with severe COVID-19 disease. Admission to the intensive care unit (ICU) was needed in 18 patients (52%), with three (2.6%) patients requiring assisted ventilation. Mortality of 2.6 per cent (3 patients) was observed. *Interpretation & conclusions:* Majority of the patients with COVID-19 infection presenting to our hospital were young and asymptomatic. Fever was noted only in three-fourth of the patients and respiratory symptoms in half of them. Patients with comorbidities were more vulnerable to complications. Triaged classification of patients and protocol-based treatment resulted in good outcomes and low case fatality.

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