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CLINICAL IMAGE
Year : 2020  |  Volume : 152  |  Issue : 7  |  Page : 57

Cyclopia syndrome with normal karyotype


Department of Pediatric Medicine, R.G. Kar Medical College and Hospital, Kolkata 700 004, West Bengal, India

Date of Submission28-Oct-2019
Date of Web Publication25-May-2021

Correspondence Address:
Debasree Guha
Department of Pediatric Medicine, R.G. Kar Medical College and Hospital, Kolkata 700 004, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_1893_19

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How to cite this article:
Banerjee S, Guha D. Cyclopia syndrome with normal karyotype. Indian J Med Res 2020;152, Suppl S1:57

How to cite this URL:
Banerjee S, Guha D. Cyclopia syndrome with normal karyotype. Indian J Med Res [serial online] 2020 [cited 2021 Jul 29];152, Suppl S1:57. Available from: https://www.ijmr.org.in/text.asp?2020/152/7/57/316737

Consent to publish clinical information and images obtained from patient's parent.


A one-eyed late preterm female neonate was born of a non-consanguineous marriage in the month of December 2018, at the department of Gynecology and Obstetrics, R.G. Kar Medical College and Hospital, Kolkata, India. A diagnosis of a case of cyclopia was made on the basis of a partially divided eye in a single orbit, absent nose, proboscis above the eye [Figure 1]. Other noticeable anomalies included Polydactyly of hand. This condition was named after the single eyed giant 'Cyclops' in Greek mythology. The aetiology remains largely unknown. Some cases may have chromosomal abnormalities (namely trisomy 13), but karyotyping in this case was normal [Figure 2]. It is the severe most expression of holoprosencephaly syndrome, with severe facial dysmorphism. Supportive management was given, but the neonate died after one hour of birth. Antenatal ultrasonography should take a lead in early detection of such rare cases incompatible with life, and termination of the pregnancy should follow.
Figure 1: The neonate having a partially divided eye in a single orbit, absent nose and proboscis above the eye.

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Figure 2: Normal karyotype map of the neonate.

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Conflicts of Interest: None.


    Figures

  [Figure 1], [Figure 2]



 

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