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CLINICAL IMAGE
Year : 2020  |  Volume : 152  |  Issue : 7  |  Page : 224-225

Birth to preschool evolution of agenesis of corpus callosum


Department of Pediatrics, Rural Medical College, Pravara Institute of Medical Sciences, Ahmednagar 413 736, Maharashtra, India

Date of Submission20-Nov-2019
Date of Web Publication25-May-2021

Correspondence Address:
Rajib Chatterjee
Department of Pediatrics, Rural Medical College, Pravara Institute of Medical Sciences, Ahmednagar 413 736, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_2376_19

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How to cite this article:
Chatterjee R, Khan A. Birth to preschool evolution of agenesis of corpus callosum. Indian J Med Res 2020;152, Suppl S1:224-5

How to cite this URL:
Chatterjee R, Khan A. Birth to preschool evolution of agenesis of corpus callosum. Indian J Med Res [serial online] 2020 [cited 2021 Jul 30];152, Suppl S1:224-5. Available from: https://www.ijmr.org.in/text.asp?2020/152/7/224/316841

Consent to publish clinical information and images obtained from patient's parent.


A three yr old male child, (LSCS at term) born to a 28 yr old G5P0L0A4 mother with history of recurrent abortions due to TORCH infection, in December 2016, was admitted to the department of Pediatrics, Pravara Rural Hospital, Rural Medical College, Loni, India. She was rubella positive for antibodies IgM. Despite antenatal fetal magnetic resonance imaging (MRI), a diagnosis of agenesis of corpus callosum (ACC) was made at 20 wk gestation, but the parents had decided to continue with the pregnancy. Low birth weight of 1940g, with ACC, mandated neonatal intensive care unit admission. Post-natal MRI, confirmed ACC [Figure 1]A, [Figure 1]B, [Figure 1]C, [Figure 1]D. Exclusively breastfed, baby was discharged on the 10th day-of-life weighing 1980g, length 46 cm, and head circumference (HC) 32 cm. Monitoring revealed prenatal onset of short stature (three-year chronological age (CA), two-year height age (HA) of 85 cm, weight of 11 kg, HC 44 cm of one-year age). However, CA>HA=BA (bone age) indicates growth potential. Growth hormone at first birthday was <3 ng/ml. Early postnatal MRI brain is recommended for early diagnosis and intervention to achieve full potential.
Figure 1: (A) Sagittal view demonstrating complete absence of all five segments of corpus callosum (rostrum, genu, body, isthmus and splenium). Absence of cingulate gyrus giving a typical spoke wheel appearance and agenesis of hippocampal commissure. (B) Post-contrast axial view demonstrating that lateral ventricles are parallel, non-converging and widely separated. (C) Post-contrast coronal view demonstrating that lateral ventricles are curved and pointed upwards giving the 'viking helmet' appearance. High riding third ventricle continuous with the inter-hemispheric fissure. (D) Colpocephaly: Axial view demonstrating occipital horns of the bilateral lateral ventricles appearing disproportionately larger than the frontal horns.

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Acknowledgment: Authors acknowledge Dr Y.P. Sachdev, department of Radiodiagnosis, RMC, PIMS, Loni, for providing radiologic images of the case.

Conflicts of Interest: None.


    Figures

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