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CLINICAL IMAGE
Year : 2020  |  Volume : 152  |  Issue : 7  |  Page : 175-176

Cutaneous & subcutaneous phaeohyphomycosis by Lasiodiplodia theobromae


Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, Uttar Pradesh, India

Date of Submission20-Nov-2019
Date of Web Publication25-May-2021

Correspondence Address:
Rungmei S.K. Marak
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_2270_19

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How to cite this article:
Nag S, Marak RS. Cutaneous & subcutaneous phaeohyphomycosis by Lasiodiplodia theobromae. Indian J Med Res 2020;152, Suppl S1:175-6

How to cite this URL:
Nag S, Marak RS. Cutaneous & subcutaneous phaeohyphomycosis by Lasiodiplodia theobromae. Indian J Med Res [serial online] 2020 [cited 2021 Aug 4];152, Suppl S1:175-6. Available from: https://www.ijmr.org.in/text.asp?2020/152/7/175/316806

Patient's consent obtained to publish clinical information and images.


A 40 yr old male on triple immunosuppression one year after renal transplantation, presented to the Microbiology department of Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, with multiple, violaceous nodules with discharging sinuses over the inter-scapular area, measuring 12 × 10 cm [Figure 1]A in October 2018. Aspirated pus showed pigmented, septate, branching fungal hyphae, suggestive of phaeohyphomycosis on KOH wet mount [Figure 1]B and Gram stain [Figure 1]C. Culture grew a black mycelial fungus ([Figure 1]D – obverse and [Figure 1]E – reverse). The isolate was confirmed as Lasiodiplodia theobromae by sequencing.
Figure 1: (A) Multiple, violaceous nodules with discharging sinuses over the inter-scapular area (at presentation). (B) KOH wet mount (×40) showing pigmented, septate, branching fungal hyphae with hyphal swellings (solid red arrow). (C) Gram stain (×100) showing septate, branching fungal hyphae with hyphal swellings (solid blue arrow). (D) Obverse of tube culture on Sabouraud dextrose agar showing black mycelial fungus (dotted blue arrow). (E) Reverse of the Sabouraud dextrose agar tube showing black mycelial fungus (dotted red arrow). (F) Lesion after three months of itraconazole therapy. (G) Skin grafting on the third post-operative day.

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The patient was treated with itraconazole (200 mg B.D. P.O.) for 12 wk [Figure 1]F, followed by wide excision and skin grafting [Figure 1]G. Post-operatively, tablet itraconazole was continued for 12 wk. On follow up, after six months grafted skin was healthy.

Conflicts of Interest: None.


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