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CLINICAL IMAGE
Year : 2020  |  Volume : 152  |  Issue : 7  |  Page : 114-115

AIDS-related disseminated Kaposi's sarcoma


Department of Dermatology, University College of Medical Sciences & Guru Teg Bahadur Hospital, New Delhi, 110 095, India

Date of Submission19-Nov-2019
Date of Web Publication25-May-2021

Correspondence Address:
Archana Singal
Department of Dermatology, University College of Medical Sciences & Guru Teg Bahadur Hospital, New Delhi, 110 095
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_2189_19

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How to cite this article:
Gaurav V, Singal A. AIDS-related disseminated Kaposi's sarcoma. Indian J Med Res 2020;152, Suppl S1:114-5

How to cite this URL:
Gaurav V, Singal A. AIDS-related disseminated Kaposi's sarcoma. Indian J Med Res [serial online] 2020 [cited 2021 Aug 4];152, Suppl S1:114-5. Available from: https://www.ijmr.org.in/text.asp?2020/152/7/114/316766

Patient's consent obtained to publish clinical information and images.


A 32 yr old male on anti-retroviral therapy presented to the Dermatology outpatient department, University College of Medical Sciences & Guru Teg Bahadur Hospital, New Delhi, India, in December 2018, with one-year history of multiple firm, discrete, erythematous to violaceous plaques and nodules [Figure 1] scattered all over the body, including oral and genital mucosa [Figure 2], which bled on manipulation since one year. He also had non-pitting oedema of the right lower limb [Figure 3] and generalized lymphadenopathy. His CD4 count was 30 cells/mm3. Ultrasonography of his right lower limb showed subcutaneous oedema and thickening. Biopsy of a skin nodule over the leg confirmed Kaposi's sarcoma (KS). Fine needle aspiration cytology from skin nodules revealed clusters comprised of oval-to-spindle cells with moderate indistinct cytoplasm, oval-to-spindle nuclei and finely granular chromatin [Figure 4]. Histopathology demonstrated unremarkable epidermis, but the underlying dermis showed circumscribed mass of spindled cells with unlined slit-like spaces and extravasated erythrocytes [Figure 5]. Immunohistochemistry revealed diffuse CD34 positivity in the endothelial cells of tumour vessels [Figure 6].
Figure 1: Multiple skin-coloured to violaceous nodules over the right lower limb.

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Figure 2: Erythematous plaque present over the right buccal mucosa.

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Figure 3: Lymphedema of the right lower limb compared to left.

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Figure 4: Cells are oval-to-spindle with moderate indistinct cytoplasm. Nuclei are oval-to-spindle with finely granular chromatin. Note low-grade nuclear features (Pap stain, ×200).

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Figure 5: High power view showing proliferation of spindle cells with numerous intervening blood-filled spaces (H and E, ×400).

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Figure 6: Immunohistochemistry showing CD34-positive endothelial cells (×400).

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Conflicts of Interest: None.


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]



 

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