Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
  Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login  
  Home Print this page Email this page Small font sizeDefault font sizeIncrease font size Users Online: 3352       

   Table of Contents      
CLINICAL IMAGE
Year : 2020  |  Volume : 152  |  Issue : 7  |  Page : 10-11

Nodular cephalic form of xanthoma disseminatum


Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi 110 029, India

Date of Submission04-Nov-2019
Date of Web Publication25-May-2021

Correspondence Address:
Neetu Bhari
Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi 110 029
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_1956_19

Rights and Permissions

How to cite this article:
Bharti P, Bhari N. Nodular cephalic form of xanthoma disseminatum. Indian J Med Res 2020;152, Suppl S1:10-1

How to cite this URL:
Bharti P, Bhari N. Nodular cephalic form of xanthoma disseminatum. Indian J Med Res [serial online] 2020 [cited 2021 Aug 4];152, Suppl S1:10-1. Available from: https://www.ijmr.org.in/text.asp?2020/152/7/10/316745

A 48 yr old female presented to the department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India, in March 2019, with yellowish papules and nodules over the periorbital areas for two years [Figure 1]A. She also noticed similar lesions over the neck for the last six months [Figure 1]B. There was no history of weight loss, bone pain, shortness of breath, polyuria or polydypsia. Skin biopsy showed diffuse infiltrate of histiocytes, foamy histiocytes and lymphocytes with Touton giant cells [Figure 1]C and [Figure 1]D. Areas of necrobiosis were not appreciated. Immunohistochemistry revealed a positive staining with CD68 with negative CD1a and S100. Systemic evaluation and investigations including those for monoclonal gammopathy and diabetes insipidus were within normal limits. A final diagnosis of nodular cephalic form of xanthoma disseminatum was made based on clinicopathological correlation.
Figure 1: (A) Periorbital yellowish papules and nodules resulting in obstruction of vision. (B) Similar confluent lesions over the neck. (C and D) Skin biopsy showed diffuse infiltration of histiocytes, lymphocytes and Touton giant cells (blue arrow) (H and E, ×100, ×400). (E and F) Flattening of skin lesions after four infusions of cladribine.

Click here to view


For the first three months, she was treated with dexamethasone pulse with daily cyclophosphamide without much improvement. Four monthly cycles of cladribine infusion (0.14 mg/kg for five days) showed 50-60 per cent improvement in her periorbital lesions and 80-90 per cent improvement in her neck lesions [Figure 1]E and [Figure 1]F. She was planned for two more monthly infusions.

Conflicts of Interest: None.


    Figures

  [Figure 1]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Article Figures

 Article Access Statistics
    Viewed270    
    Printed0    
    Emailed0    
    PDF Downloaded32    
    Comments [Add]    

Recommend this journal