Clinico-demographic profile & hospital outcomes of COVID-19 patients admitted at a tertiary care centre in north India
Anant Mohan1, Pawan Tiwari1, Sushma Bhatnagar2, Ankit Patel1, Abhishek Maurya1, Lalit Dar3, Sourabh Pahuja1, Rakesh Garg2, Nishkarsh Gupta2, Biswajeet Sahoo4, Ritu Gupta5, Ved Prakash Meena6, Saurabh Vig2, Anuja Pandit2, Saurabh Mittal1, Karan Madan1, Vijay Hadda1, Tanima Dwivedi4, Aashish Choudhary3, Megha Brijwal3, Manish Soneja6, Randeep Guleria7, Brajesh Ratre2, Balbir Kumar2, Shweta Bhopale2, Smriti Panda8, Angel Rajan Singh9, Sheetal Singh5, Laxmitej Wundavalli5
1 Department of Pulmonary, Critical Care & Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India
2 Department of Onco-Anaesthesia & Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India
3 Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
4 Department of Laboratory Oncology, National Cancer Institute, All India Institute of Medical Sciences, Jhajjar, Haryana, India
5 Department of Hospital Administration, National Cancer Institute, All India Institute of Medical Sciences, Jhajjar, Haryana, India
6 Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
7 All India Institute of Medical Sciences, New Delhi, India
8 Department of Otolaryngology & Head-Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
9 Department of Hospital Administration, All India Institute of Medical Sciences, New Delhi, India
Department of Pulmonary, Critical Care & Sleep Medicine, All India Institute of Medical Sciences, New Delhi 110 029
Source of Support: None, Conflict of Interest: None
Background & objectives: In December 2019, a novel coronavirus (SARS-CoV-2) emerged in China and rapidly spread globally including India. The characteristic clinical observations and outcomes of this disease (COVID-19) have been reported from different countries. The present study was aimed to describe the clinico-demographic characteristics and in-hospital outcomes of a group of COVID-19 patients in north India.
Methods: This was a prospective, single-centre collection of data regarding epidemiological, demographic, clinical and laboratory parameters, management and outcome of COVID-19 patients admitted in a tertiary care facility in north India. Patient outcomes were recorded as death, discharge and still admitted.
Results: Data of 144 patients with COVID-19 were recorded and analyzed. The mean age of the patients was 40.1±13.1 yr, with 93.1 per cent males, and included 10 (6.9%) foreign nationals. Domestic travel to or from affected States (77.1%) and close contact with COVID-19 patients in congregations (82.6%) constituted the most commonly documented exposure. Nine (6.3%) patients were smokers, with a median smoking index of 200. Comorbidities were present in 23 (15.9%) patients, of which diabetes mellitus (n=16; 11.1%) was the most common. A significant proportion of patients had no symptoms (n=64; 44.4%); among the symptomatic, cough (34.7%) was the most common symptom followed by fever (17.4%) and nasal symptoms (2.15%). Majority of the patients were managed with supportive treatment with hydroxychloroquine and azithromycin given on a case-to-case basis. Only five (3.5%) patients required oxygen supplementation, four (2.8%) patients had severe disease requiring intensive care, one required mechanical ventilation and mortality occurred in two (1.4%) patients. The time to reverse transcription-polymerase chain reaction (RT-PCR) negativity was 16-18 days.
Interpretation & conclusions: In this single-centre study of 144 hospitalized patients with confirmed COVID-19 in north India, the characteristic findings included younger age, high proportion of asymptomatic patients, long time to PCR negativity and low need for intensive care unit care.