Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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Year : 2019  |  Volume : 150  |  Issue : 5  |  Page : 508-511

Status of adult immunity to hepatitis A virus in healthcare workers from a tertiary care hospital in north India

1 Department of Internal Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India
2 Department of Microbiology, Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
3 Department of Microbiology, King George's Medical University, Lucknow, Uttar Pradesh, India

Correspondence Address:
Dr D Himanshu
Department of Internal Medicine, King George's Medical University, Lucknow 226 003, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijmr.IJMR_787_18

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Background & objectives: Humans are considered to be the principal host for hepatitis A virus (HAV) infection. In India, heterogeneous groups of susceptible individuals coexist in different regions. There has been a decline in antibody titres to HAV among young adults which may pose a major public health problem. The objective of this study was to assess the IgG anti-HAV level among healthcare workers (HCWs) in the age group of 20-60 yr and its association with the socio-demographic variables. Methods: Blood sample (2 ml) was collected under aseptic conditions from each participant followed by the preparation of serum and storing at −20°C. ELISA-based kits were used for the determination of IgG antibodies to HAV in the human serum samples. Results: Two hundred and fifty four HCWs were enrolled. IgG anti-HAV antibodies were detected in 97.2 per cent of the samples analyzed. No differences were observed in the levels of IgG anti-HAV antibody and education, income, occupation and socio-economic classes of the HCWs. A seropositivity rate of over 90 per cent was seen amongst all the socio-economic classes. Interpretation & conclusions: High levels of IgG protective antibodies were seen among the studied HCWs, hence HAV vaccination may not be required. It will be advisable to do a cost-benefit analysis of vaccination for HAV.

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