Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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Year : 2018  |  Volume : 147  |  Issue : 3  |  Page : 233-238

Host-targeted therapy for tuberculosis: Time to revisit the concept

Department of Microbiology, National Reference Laboratory for Tuberculosis, Bhopal Memorial Hospital & Research Centre, Bhopal, India

Correspondence Address:
Dr Prabha Desikan
Department of Microbiology, Bhopal Memorial Hospital & Research Centre, Bhopal 462 038, Madhya Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijmr.IJMR_652_17

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Tuberculosis (TB) is an important cause of morbidity and mortality worldwide. Every year millions of people die due to TB. Drug resistance has been a major factor that has obstructed successful control and treatment of TB. As the rate of spread of drug-resistant TB outpaces the rate of discovery of new anti-tubercular drugs, targeted therapy may provide a new approach to TB cure. In a scenario where drug resistance is spreading rapidly, and existing drugs regimens seem to be dwindling away, this review summarizes the concept of host-targeted therapy which may be the ray of hope for the effective management and control of the rapidly spreading drug-resistant TB (multidrug resistant and extensively drug resistant).

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