| ORIGINAL ARTICLE |
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| Year : 2017 | Volume
: 146
| Issue : 3 | Page : 369-374 |
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Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury
Oguz Kayiran1, Suat Sedat Cuzdan2, Afsin Uysal3, Ugur Kocer4
1 Department Plastic & Reconstructive Surgery, Izmir University, Izmir, Turkey
2 Plastic Surgery Clinic, Sanmed Private Hospital, Sanliurfa, Turkey
3 Plastic & Reconstructive Surgery Clinic, TOBB ETU Hospital, Ankara, Turkey
4 Plastic & Reconstructive Surgery Clinic, Ankara Training & Research Hospital, Ankara, Turkey
Correspondence Address:
Dr Oguz Kayiran
Baltalimani Training and Research Hospital, Plastic & Reconstructive Surgery Clinic, Rumelihsari Cd, No:62, Baltalimani, Sariyer
Turkey
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijmr.IJMR_1428_14
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Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats.
Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase).
Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P<0.05) in the levels of these markers between ischaemic and medication groups. Ethyl pyruvate improved all the parameters significantly.
Interpretation & conclusion: Ethyl pyruvate showed strong scavenger activity against reactive oxygen species. It could be a potential candidate to improve the flap viability in reconstructive microsurgery, especially in free tissue transfers. However, more studies are warranted in experimental models to confirm these findings.
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