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ORIGINAL ARTICLE
Year : 2017  |  Volume : 146  |  Issue : 3  |  Page : 369-374

Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury


1 Department Plastic & Reconstructive Surgery, Izmir University, Izmir, Turkey
2 Plastic Surgery Clinic, Sanmed Private Hospital, Sanliurfa, Turkey
3 Plastic & Reconstructive Surgery Clinic, TOBB ETU Hospital, Ankara, Turkey
4 Plastic & Reconstructive Surgery Clinic, Ankara Training & Research Hospital, Ankara, Turkey

Correspondence Address:
Dr Oguz Kayiran
Baltalimani Training and Research Hospital, Plastic & Reconstructive Surgery Clinic, Rumelihsari Cd, No:62, Baltalimani, Sariyer
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_1428_14

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Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase). Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P<0.05) in the levels of these markers between ischaemic and medication groups. Ethyl pyruvate improved all the parameters significantly. Interpretation & conclusion: Ethyl pyruvate showed strong scavenger activity against reactive oxygen species. It could be a potential candidate to improve the flap viability in reconstructive microsurgery, especially in free tissue transfers. However, more studies are warranted in experimental models to confirm these findings.


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