Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
  Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login  
  Home Print this page Email this page Small font sizeDefault font sizeIncrease font size Users Online: 2356       
ORIGINAL ARTICLE
Year : 2017  |  Volume : 146  |  Issue : 3  |  Page : 341-345

Impact of embryo co-culture with cumulus cells on pregnancy & implantation rate in patients undergoing in vitro fertilization using donor oocyte


1 Department of Biochemistry, P.D. Patel Institute of Applied Sciences, Charotar University of Science & Technology, Changa; Department of IVF, Akanksha Hospital & Research Institute, A Unit of Sat Kaival Hospital Pvt. Ltd., Anand, India
2 Department of IVF, Akanksha Hospital & Research Institute, A Unit of Sat Kaival Hospital Pvt. Ltd., Anand, India
3 Central Research Services, Charutar Arogya Mandal, Karamsad, India
4 Department of Biochemistry, P.D. Patel Institute of Applied Sciences, Charotar University of Science & Technology, Changa, India

Correspondence Address:
Dr Jagdish S Patel
Department of Biochemistry, P.D. Patel Institute of Applied Sciences, Charotar University of Science & Technology, Changa, Petlad, Anand 388 421, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_1702_15

Rights and Permissions

Background & objectives: Cumulus cell co-culture of embryo had been found to be beneficial for achieving better pregnancy and implantation rate (IR). The present study was aimed to evaluate efficiency of cumulus co-culture technique over simple culture of embryo in terms of pregnancy rate (PR) and IR in patients undergoing treatment for infertility using donor oocytes fertilized by intracytoplasmic sperm injection. Methods: This was a quasi-experimental study between control and study groups. The primary endpoint was achievement of pregnancy. Control group included 508 women who underwent embryo development without cumulus cell co-culture and study group included 394 women who underwent embryo development with cumulus cell co-culture using donor's cumulus cells. Results: The present study demonstrated a significant increase in the IR (37.2 vs 24.2%, P<0.001) and in PR (45.7 vs 37.8%, P<0.05) in study group than in control group. The PR and IR were found to be higher in study group, among all groups of women, grouped on the basis of different indications for use of donor oocytes. Interpretation & conclusions: Cumulus cell co-culture technique was found to be more effective than simple culture technique for embryo development in women undergoing treatment for infertility using donor oocytes fertilized by intracytoplasmic sperm injection.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed916    
    Printed5    
    Emailed0    
    PDF Downloaded202    
    Comments [Add]    

Recommend this journal