Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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REVIEW ARTICLE
Year : 2017  |  Volume : 145  |  Issue : 6  |  Page : 730-737

Telomere length as a potential biomarker of coronary artery disease


1 Department of Cardiac Research, Cumballa Hill Hospital & Heart Institute, Mumbai, India
2 Department of Hematology & Oncology, Research Institute for Radiation Biology & Medicine, Hiroshima University, Hiroshima, Japan

Correspondence Address:
Joyeeta Bhattacharyya
Department of Cardiac Research, Cumballa Hill Hospital & Heart Institute, 93-95 August Kranti Marg, Mumbai 400 036, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-5916.216974

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Coronary artery disease (CAD) is a multifactorial disease whose prevalence remains unabated especially in developing countries. Both lifestyle factors and genetic predisposition contribute to this disorder. Though notable achievements have been made in the medical, interventional and surgical management of CAD, the need for its prevention is more important. Among other modalities, this calls for defining evidence-based new biomarkers, which on their own or in combination with other known biomarkers may predict the risk of CAD to enable institution of appropriate preventive strategies. In the present communication, we have discussed the usefulness of shortening of telomeres as a potential biomarker of CAD. Clinical research evidence in favour of telomere shortening in CAD is well documented in different ethnic populations of the world. Establishing a well-standardized and accurate method of evaluating telomere length is essential before its routine use in preventive cardiology.


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