|Year : 2017 | Volume
| Issue : 5 | Page : 593-600
Diagnosis of polymyalgia rheumatica usually means a favourable outcome for your patient
Marcin Milchert, Marek Brzosko
Department of Rheumatology, Internal Medicine & Geriatrics, Pomeranian Medical University, Szczecin, Poland
|Date of Submission||20-Feb-2017|
|Date of Web Publication||25-Sep-2017|
Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University, Szczecin, ul Unii Lubelskiej 1, 71-252 Szczecin
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Polymyalgia rheumatica (PMR) is a unique disease of elderly people, traditionally diagnosed based on a clinical picture. A typical case is a combination of severe musculoskeletal symptoms and systemic inflammatory response with spectacular response to corticosteroids treatment. The severity of symptoms may be surprising in older patients where immunosenescence is normally expected. However, PMR may be diagnosed in haste if there is a temptation to use this diagnosis as a shortcut to achieve rapid therapeutic success. Overdiagnosis of PMR may cause more problems compared to underdiagnosis. The 2012 PMR criteria proposed by European League against Rheumatism/American College of Rheumatology aim to minimize the role of clinical intuition and build on more objective features. However, questions arise if this is possible in PMR. This has been discussed in this review.
Keywords: Classification criteria - corticosteroids - diagnosis - musculoskeletal - polymyalgia rheumatica
|How to cite this article:|
Milchert M, Brzosko M. Diagnosis of polymyalgia rheumatica usually means a favourable outcome for your patient. Indian J Med Res 2017;145:593-600
|How to cite this URL:|
Milchert M, Brzosko M. Diagnosis of polymyalgia rheumatica usually means a favourable outcome for your patient. Indian J Med Res [serial online] 2017 [cited 2021 May 16];145:593-600. Available from: https://www.ijmr.org.in/text.asp?2017/145/5/593/215554
| Introduction|| |
Polymyalgia rheumatica (PMR) is an auto-inflammatory rheumatic disease of people over 50 years, presenting with pain and stiffness in the neck, shoulder and hip girdles . The term PMR was first used to underline that it seemed substantially milder from rheumatoid arthritis (RA) as no joint damage had been observed . However, this name may be misleading as PMR is a disease but not a non-specific myalgic or paraneoplastic syndrome. Secondary PMR does not exist. The short definition of PMR may be also misunderstood as it does not suggest how unique the clinical picture of 'musculoskeletal pain and stiffness' might be. What makes PMR so special is a sudden onset of severe musculoskeletal symptoms that strongly reduce daily performance and quality of life, together with systemic inflammatory reaction in elderly but usually generally healthy patient, frequently accompanied by depressive reaction, lack of pathognomonic laboratory or radiologic findings, and splendid reaction to low-dose corticosteroids (CSs). Strong auto-inflammatory response is normally unexpected in an elderly patient, but immunosenescence  seems not to apply in PMR. Good prognosis is also surprising as there is no good explanation to the fact that PMR patients apparently live longer than matched controls ,. However, PMR is frequently accompanied by giant cell arteritis (GCA). Therefore, there is an increased probability of all the ischaemic complications related to GCA in PMR . Further, generally favourable outcome of PMR may be easily wasted in case of excessive CSs treatment, resulting in side effect that eventually worsens patient's quality of life .
The aim of this review article is to discuss about correct diagnosis of PMR.
| Epidemiology|| |
Annual incidence of PMR is up to 50/100,000 population over 50 yr . It is uncommon in India ,. The highest prevalence is found in Caucasians, in Northern European countries, especially in Scandinavia. Vikings' ancestry is associated with increased risk of PMR (marked by migration from Scandinavia , in Western European lands invaded by Normands  or Eastern European settled by Varangians ). The incidence grows with age, starting from 50 yr, with peak above 70 yr . It is easier to find a report of wrong diagnosis of PMR in patients under 50 yr , than an undoubtful case report of PMR or GCA in young .
| Polymyalgia Rheumatica Versus Giant Cell Arteritis|| |
PMR and GCA are closely related. These have similar genetic background and epidemiology, and frequently overlap . However, PMR represents a non-specific immune-mediated inflammatory reaction triggered by innate immunity activation. GCA is manifested by vascular inflammation caused by faulty adaptive immune reaction that is mainly T cell dependent . The clinical outcome is so different that it is continuously debated why some patients express only one pathway. Evidence of vascular inflammation in needed to diagnose GCA. It is usually recorded in about 10 per cent of PMR patients , but detailed vascular examination may substantially increase that percentage . The historical term polymyalgia arteritica  might still be accurate because it underlines suspected vascular pathogenesis of PMR. Silent vasculitis has been demonstrated in some of PMR patients . Regardless of PMR and GCA pathophysiologic relations, from a practical point of view, it must not be forgotten that patients diagnosed with PMR are also at an increased risk of GCA-associated complications. The concomitant GCA implies the need for more aggressive treatment strategy [Table 1]. PMR symptoms can dominate over the clinical picture of GCA. Small CSs doses used for PMR do not suppress concomitant GCA (although this is more generally accepted than proved opinion) that may progress to cause blindness.
|Table 1: Differences in treatment strategy underlining the need for identifying concomitant giant cell arteritis (GCA) in patients with polymyalgia rheumatic (PMR)|
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| When Should Polymyalgia Rheumatica Be Suspected?|| |
Proximal, musculoskeletal pain and stiffness are the leading manifestations and these raise little doubts about the diagnosis in a typical PMR case. However, PMR pivotal manifestations may be less specific: fewer or raised C-reactive protein (CRP) of unknown origin, general weakness, weight loss, depressive reaction, decompensation of chronic diseases (e.g. chronic heart failure) due to increased metabolism ,.
| How to Diagnose Polymyalgia Rheumatica?|| |
There is no universal answer to this question. Although clinical presentation is typical, in some cases, the disease may be surprising. The best strategy is a combination of different approaches (based on clinical picture, classification criteria, exclusions and ex juvantibus diagnosing), together with extensive diagnostics and follow up observation of atypical cases . Ninety per cent of rheumatologists in the United Kingdom (UK) declare the use of the classification criteria for PMR diagnosis although they admit not to adhere to the guidelines to exclude other diseases . This approach may be accepted only in countries with high incidence of PMR resulting in relatively low number of PMR mimics .
| Diagnosis Based on Clinical Picture|| |
Clinical assessment is most important for PMR diagnosis. There are no specific antibodies (PMR and GCA are T cell-dependent diseases ,) or additional testing to confirm PMR. Clinical manifestations come from a combination of musculoskeletal pain and stiffness and acute inflammatory response, which is quite different in elderly compared to young patients.
It is difficult to find PMR case without bilateral pain and stiffness of muscles and joints of neck, shoulder and hip girdles. Generalized musculoskeletal pain is not a PMR manifestation. Small joints involvement is also not typical but may be rarely found . Shoulder girdle involvement usually appears first and may gradually extend to the area of neck and hip girdle. Symmetrical involvement is typical. The pain worsens during the night, typically waking the patient from sleep between 0400 and 0600 h in the morning. Morning stiffness of more than one hour is more specific for PMR than the pain, but the pain is more commonly reported. Pain may overwhelm the symptoms of stiffness. Limitations of upper limbs elevation make it difficult for the patient to comb his/her hair or pray in the morning. It is illustrated by the way patients get up out of bed: large joints stiffness makes them to rock the whole body to slip out beyond the edge of bed. However, after overcoming morning stiffness, patients can usually perform their daily activities fairly well. The feeling of stiffness can also reoccur during the day, after a period of immobility. In extreme cases, musculoskeletal stiffness may cause even a daylong immobilization. However, the course may also be self-limiting. Patients report limb weakness by which they understand the limitation of motion due to stiffness and pain. In contrast with polymyositis, PMR does not cause actual muscle weakness ,. Bilateral tenderness of proximal muscles is a valuable sign both for the diagnosis and treatment monitoring.
Manifestations associated with inflammatory response or deterioration of general state
It is surprising in PMR patient as to how intense inflammatory reaction in elderly may manifest. However, it is also possible to cause anergy-like state with depressive reaction and cachexia. In both situations, PMR may be confused with symptoms of premature ageing both by patients and their physicians . Acute or sub-acute onset of the disease (up to 2 wk) is characteristic, which means a sudden deterioration of daily performance and reduced quality of life. It may appear striking in an older patient who was previously coping well with his/her daily activities. Depressive reaction may be the first or the leading manifestation. Inflammatory reaction in elderly can manifest atypically, by reduction of psychomotor activity and decreased appetite. They can be difficult to differentiate from the endogenous depression. Pro-depressive characteristics of interleukin-6 (IL-6), which plays substantial role in PMR pathogenesis , should be taken into account for a better explanation of this phenomenon . Another reason for behavioural change in PMR patients may be an adaptive response associated with rapid deterioration of physical performance, causing anxiety of getting old and loosing self-reliance . Weight loss is a common manifestation and may progress severely. Low-grade fever and night sweats may persist for months. Patients describe it as 'a flu that does not go away',,.
These are possible but frequently remain controversial. These include atypical musculoskeletal manifestations (distal or asymmetrical joints involvement, sternoclavicular joints involvement, lack of shoulder girdle involvement, lack of morning stiffness), younger age at the disease onset, normal erythrocyte sedimentation rate (ESR) and CRP serum levels, lack of good response to CSs treatment ,.
| Diagnosis Based on the Classification Criteria|| |
Classification criteria are not developed for diagnosing but are generally used for this purpose. Systems of classification of the diseases are demanded by clinical trials, public health and insurance systems. These criteria define most typical manifestation of the disease and provide an organized summary of its main manifestations. That is why the 'old' criteria such as formulated by Bird et al or Jones and Hazleman  are still valid as these were formulated based on clinical observation [Table 2]. Yet, PMR is not a disease diagnosed by simple ticking signs and symptoms on a checklist. If it were so, a coincidence of depression and shoulder joints osteoarthritis (OA) in an elderly patient would be misclassified as PMR according to Bird's criteria. The interpretation of the importance of complaints and findings in an individual patient by an expert remains fundamental for PMR diagnosis. Shoulder girdle pain must have inflammatory character and depression cannot be endogenous to be accounted in Bird's criteria. Jones and Hazleman's criteria have a potential superiority in countries with low PMR prevalence as they have a higher specificity and include a list of most important exclusions.
|Table 2: Summary of similar classification criteria for polymyalgia rheumatic a (PMR)|
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In 2012, European League against Rheumatism (EULAR) and American College of Rheumatology (ACR) formulated new classification criteria for PMR [Figure 1],. These may only be applied in patients meeting preliminary criteria: age over 50 yr, bilateral shoulder aching, elevated CRP or ESR. These are a good example of classification philosophy to reduce heterogeneity of positively classified cases by selecting the subset of the most typical manifestations. Therefore, these criteria are not to be met in atypical cases of PMR. On the other hand, these have a potential to reduce the rate of false positive diagnosis .
|Figure 1: Patient meeting preliminary criteria must score at least 4 points to be classified as polymyalgia rheumatica (PMR) according to European League against Rheumatism/American College of Rheumatology criteria, which gives three possible scenarios encompassing the combination of 2 points for morning stiffness; 2 points for absence of rheumatoid arthritis specific antibodies; 1+1 point for hip girdle involvement and absence of other joint involvement. Source: Ref 39.|
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Musculoskeletal ultrasound gains importance in rheumatology. PMR criteria integrated ultrasonographic evaluation into classification process for the first time in rheumatology . Ultrasound criterion requires examining both shoulders (for glenohumeral synovitis, bursitis or biceps tenosynovitis) and hips (for joint synovitis or trochanteric bursitis). The intention for this is assessment of the symmetry of changes between inflammatory changes in both shoulders and between upper and lower limbs involvement. Each of these will score an additional point to the scoring algorithm. Final sum of five out of eight (6 from algorithm without ultrasound plus 2 from ultrasound examination) points enables to classify a patient as PMR with 66 per cent sensitivity and 81 per cent specificity . Ultrasound evaluation is relatively simple to perform as the findings of merely the presence of joint effusion, tenosynovitis or bursitis are sufficient. However, these abnormalities are hardly specific for PMR. A short ultrasound examination of proximal joints usually fails to demonstrate differences between inflammatory joint diseases. The differentiation between PMR and RA is a common dilemma. A more detailed ultrasound assessment can demonstrate joints' erosions and extensive synovial proliferation of both small and large joints that are more typical for RA. Ultrasound can demonstrate degenerative or post-traumatic joint lesions as well as detect GCA overlap  [Figure 2].
|Figure 2: Ultrasound examination of glenohumeral joint from axillary approach revealing no significant effusion inside a joint capsule (bottom of the picture). With the same approach, axillary artery is simultaneously examined with colour duplex ultrasound (left, upper side of the picture): it reveals homogenous, hypoechoic vessel wall thickening of 1 mm (indicated between “+” signs), well delineated towards the luminal side being consistent with axillary arteritis.|
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Additional tests to help with the diagnosis
There are no pathognomonic antibodies or other PMR-specific markers discovered. Although ESR and CRP serum levels are not specific, it is hard to find PMR with normal inflammatory parameters . Other acute phase markers (fibrinogenemia, thrombocythemia and elevated IL-6, the latter correlates best with the disease activity ) are also present. Anaemia of chronic disease type is common and is reversed shortly after CSs treatment initiation. Sometimes, slightly increased transaminases and alkaline phosphatase levels are present. Sparse studies indicated a significantly higher occurrence of anti-phospholipid antibodies, but these have not been proved to be associated with ischaemic or thromboembolic complications ,,,.
The benefits and drawbacks of classification criteria sets must be duly considered before applying them for diagnosis. The 2012 proposed EULAR/ACR PMR criteria  (opposed to the previous sets) aim to minimize the role of clinical intuition and build on more objective features and additional tests. However, ESR, rheumatoid factor and ultrasound changes still have only limited specificity. The drawbacks of all of the PMR criteria sets are their unsatisfactory sensitivity and specificity. They were also formulated in populations with a high PMR prevalence. If classification criteria are not met (which usually takes place in atypical PMR), the disease should not be diagnosed hastly but only after excluding other causes of similar symptoms ,.
| Diagnosis by Excluding Other Causes of Similar Symptoms|| |
The need for considering PMR exclusions was underlined in the previous criteria  and is also found in the current guidelines . The typical clinical picture of PMR requires only basic differential diagnostics. The more atypical the clinical picture, the wider differential diagnostics is required. The differential diagnostics in countries with low PMR incidence requires considering the relatively higher number of PMR mimics. It was illustrated in a study from Turkey that 30 per cent of patients with final PMR diagnosis were hospitalized, 30 per cent were treated with antibiotics, and in 29, 22 and 19 per cent abdominal, chest and brain computed tomography (CT), respectively, were performed. This approach seemed reasonable; however, there were still 13±13 months delay from onset of symptoms to diagnosis .
Why do PMR-like manifestations mask the symptoms of other diseases? PMR pathogenesis is mediated by innate immunity. It triggers non-specific inflammatory reaction which is not unique for PMR . Acute inflammatory response can mask more characteristic symptoms of a disease that are not reported by patients. For example, elderly onset RA may go with systemic inflammatory manifestations and large joint involvement that cause patient immobilization. Therefore, small joints inflammation is not reported by a patient whose main complaint is inability to get out of bed. Further, serious, GCA-associated ischaemic manifestations (such as double vision or jaw claudication that are typical prodromal symptoms of vision loss) can be unreported by patients seeking medical advice because of much more disturbing manifestations of overlapping PMR. Paraneoplastic syndromes that can be manifested long before an appearance of symptoms associated with tumour growth may also be misclassified as PMR .
Differential diagnosis of conditions associated with musculoskeletal symptoms
Differentiation between PMR and seronegative, elderly onset RA affecting proximal joints is actually a common reason for diagnostic uncertainty. It may also be a case if bilateral painful shoulder syndrome coexists with depression and elevated ESR. Ultrasound examination of the shoulder joints may be helpful in determining the cause of the pain. Diagnosing the sources of inflammatory reaction and mood disorders in the elderly may be demanding, requiring knowledge on geriatrics. Musculoskeletal symptoms resembling PMR may originate from myopathy due to hypo- or hyperthyroidism, CSs or statins use, amyloidosis; Addison's disease (also adynamia suggesting depression and a good response to CSs),.
Differential diagnosis of conditions associated with inflammatory response or deterioration of general state
Typical PMR age group is associated with a high risk of cancer. Manifestations of PMR may also resemble paraneoplastic syndromes. However, PMR frequently starts suddenly and manifests more dynamically. Spontaneous remission, which can occur in PMR, is unusual for cancer. A 1.7-fold increase in the rate of cancer diagnoses was noted in the first six months of PMR observation in the UK, compared to age- and sex-matched patients with no PMR . Attempts should be made to minimize this period by differential diagnostics and careful observation of atypical PMR cases . Some of the PMR symptoms (fever, night sweats and joint pain) may suggest systemic lupus erythematosus or other autoimmune diseases and infectious diseases, including endocarditis or tuberculosis. Focus on musculoskeletal pain can mask the endogenous or reactive depression being the real cause of deterioration of patient's state.
Due to PMR and GCA overlap, physical examination of PMR patients should encompass temporal arteries (for tenderness, loss of pulsation) and large arteries analogically to Takayasu arteritis (upper and lower limbs intermittent claudication, differences in blood pressure between both limbs, presence of vascular bruits). Treatment-resistant PMR indicates a special need for imaging of large arteries for overlapping vasculitis. It may include ultrasound examination of temporal and large (axillary, sub-clavian, common carotid) arteries by a specialist experienced in differentiating vascular wall inflammation from arteriosclerosis, as well as assessment of the aorta and its branches with contrasted computed tomography (CT), magnetic resonance imaging (MRI) or positron emission tomography (PET) with CT ,. Lack of GCA manifestations at the time of PMR diagnosis should not stop the awareness of developing vasculitis during follow up. Small CSs doses used for PMR do not protect against the progression of arterial inflammation . PMR patients should be educated to immediately seek medical advice in case of vision disturbance (double vision, transient ischaemic attacks), jaw claudication or scalp tenderness.
| Diagnosis Ex Juvantibus|| |
Rapid and spectacular improvement shortly after CSs introduction enables concluding on a cause based on an observed response to the treatment. Therefore, PMR patients are much pleased shortly after treatment initiation and grateful to their doctors . Lack of improvement within five days suggest a need to verify the PMR diagnosis (to some different disease or GCA). Diagnosis ex juvantibus was included in Jones and Hazleman's criteria . New, 2012 PMR classification criteria do not include a good response to CSs in the diagnostic process . It raised some discussion as this criterion is widely used in a daily practice . It was argued that treatment response was non-specific and difficult to define feature. Indeed, elderly onset RA or other inflammatory conditions also respond well to CSs. However, this response would be weak in OA and transient if applied in infection or neoplasm. In these cases review of the initial PMR diagnosis is needed. It is not a mistake to reassess the initial diagnosis and change it accordingly. About 10 per cent of patients initially diagnosed with PMR are later reclassified as having elderly onset RA . For that purpose, careful monitoring of patients is needed. PMR patients require regular medical check-ups.
Diagnosing ex juvantibus may also be made eagerly because it does not require an effort of time-consuming and expensive procedures. Spectacular efficacy of CSs in PMR may cause a temptation to overuse them. There has been increased interest in GCA and PMR evoked by modern treatment possibilities , and fast track GCA clinics . Based on our own experience, PMR is easy to overdiagnose. Establishing rational PMR diagnosis illustrates a challenge to resist fashion and wishful thinking in medicine. Adherence to the 2012 PMR classification criteria could be beneficial in preventing overdiagnosis because these do not include response to therapy. However, the 'response criterion' will not disappear from the daily practice of the physicians who can appreciate how unique PMR symptoms react to CSs. At least as long as there are no better disease markers.
| Conclusion|| |
Lack of specific biomarkers of PMR is problematic and research is needed. Up to now, the diagnosis remains clinical. There are many clinical subtleties to be considered. Usually, PMR responds well to CSs treatment and outcomes are favourable. However, differential diagnosis encompasses diseases with bad prognosis; therefore, PMR overdiagnosis can be detrimental.
Conflicts of Interest: None.
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[Figure 1], [Figure 2]
[Table 1], [Table 2]